| Autor: |
Amin HIM; Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil 44001, Iraq.; Department of Medical Biochemical Analysis, Cihan University-Erbil, Erbil 44001, Iraq., Abdoulrahman K; Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil 44001, Iraq., Sadraddin AS; Department of Chemistry, College of Education, Salahaddin University-Erbil, Erbil 44001, Iraq., Smail HA; Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil 44001, Iraq., Jawhar ZH; Department of Science, College of Health Science, Lebanese French University, Erbil 44001, Iraq., Dilawer Issa K; Department of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil 44001, Iraq., Armijos C; Departamento de Química, Universidad Técnica Particular de Loja (UTPL), Loja 1101608, Ecuador., Vidari G; Department of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil 44001, Iraq.; Department of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy. |
| Abstrakt: |
The volatile oils hydrodistilled from the aerial parts and roots of O. carduchorum C.C Towns. (Fabaceae) have been chemically characterized for the first time. A total of 43 constituents with an abundance >0.03% were identified and quantified in the two oils by GC/MS and GC/FID analyses. They comprise 38 components (98.58%) of the oil isolated from the aerial parts (OCA) and 34 components (93.33%) of the oil from the roots (OCR). Six constituents, α-pinene (23.11 ± 0.1%), β-elemene (17.33 ± 0.1%), 1,8-cineole (12.15 ± 0.2%), furfural (7.91 ± 0.1%), terpineol-4-ol (6.32 ± 0.2%), and limonene (4.13 ± 0.1%), accounted for about 75% of the total OCA oil. On the other hand, 1,8-cineole (15.79 ± 0.1%), furfural (10.44 ± 0.1%), β-elemene (10.14 ± 0.2%), α-terpineol (7.74 ± 0.1%), linalool (7.45 ± 0.1%), and α-pinene (4.76 ± 0.1%) made up about 60% of the OCR oil. The IC 50 values of the scavenging activities of the OCA and OCR oils towards the DPPH radical and H 2 O 2 were 79.8 ± 0.5 and 153.3 ± 0.6 μg/mL and 394.09 ± 0.2 and 311.67 ± 0.4 μg/mL, respectively. In addition, in the MTS assay, the OCA and OCR oils showed significant antiproliferative effects against T47D, MDA-MB-453, BG-1, and A549 human cancer cells that were more powerful than those against two normal human cell lines, HEK-293 and HFF-1. The abundant presence of β-elemene as an antiproliferative component of the two oils suggested the existence of a new chemotype of O. carduchorum . |
