| Autor: |
Pantazi AC; Pediatrics Department, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Pediatrics Department, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Balasa AL; Pediatrics Department, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Pediatrics Department, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Mihai CM; Pediatrics Department, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Pediatrics Department, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Chisnoiu T; Pediatrics Department, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Pediatrics Department, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Lupu VV; Pediatrics Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Kassim MAK; Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania., Mihai L; Pediatrics Department, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Pediatrics Department, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Frecus CE; Pediatrics Department, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Pediatrics Department, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Chirila SI; Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania., Lupu A; Pediatrics Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Andrusca A; Pediatrics Department, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Pediatrics Department, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Ionescu C; Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania., Cuzic V; Pediatrics Department, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Pediatrics Department, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Cambrea SC; Infectious Diseases Department, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania. |
| Abstrakt: |
The first 1000 days after birth represent a critical window for gut microbiome development, which is essential for immune system maturation and overall health. The gut microbiome undergoes major changes during this period due to shifts in diet and environment. Disruptions to the microbiota early in life can have lasting health effects, including increased risks of inflammatory disorders, autoimmune diseases, neurological disorders, and obesity. Maternal and environmental factors during pregnancy and infancy shape the infant gut microbiota. In this article, we will review how maintaining a healthy gut microbiome in pregnancy and infancy is important for long-term infant health. Furthermore, we briefly include fungal colonization and its effects on the host immune function, which are discussed as part of gut microbiome ecosystem. Additionally, we will describe how potential approaches such as hydrogels enriched with prebiotics and probiotics, gut microbiota transplantation (GMT) during pregnancy, age-specific microbial ecosystem therapeutics, and CRISPR therapies targeting the gut microbiota hold potential for advancing research and development. Nevertheless, thorough evaluation of their safety, effectiveness, and lasting impacts is crucial prior to their application in clinical approach. The article emphasizes the need for continued research to optimize gut microbiota and immune system development through targeted early-life interventions. |
