| Autor: |
Aggeletopoulou I; Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece., Kalafateli M; Department of Gastroenterology, General Hospital of Patras, 26332 Patras, Greece., Tsounis EP; Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece., Triantos C; Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 16; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 16. |
| DOI: |
10.3390/ijms241612864 |
| Abstrakt: |
Nonalcoholic fatty liver disease (NAFLD), the most prominent cause of chronic liver disease worldwide, is a rapidly growing epidemic. It consists of a wide range of liver diseases, from steatosis to nonalcoholic steatohepatitis, and predisposes patients to liver fibrosis, cirrhosis, and even hepatocellular carcinoma. NAFLD is strongly correlated with obesity; however, it has been extensively reported among lean/nonobese individuals in recent years. Although lean patients demonstrate a lower prevalence of diabetes mellitus, central obesity, dyslipidemia, hypertension, and metabolic syndrome, a percentage of these patients may develop steatohepatitis, advanced liver fibrosis, and cardiovascular disease, and have increased all-cause mortality. The pathophysiological mechanisms of lean NAFLD remain vague. Studies have reported that lean NAFLD demonstrates a close association with environmental factors, genetic predisposition, and epigenetic modifications. In this review, we aim to discuss and summarize the epigenetic mechanisms involved in lean NAFLD and to introduce the interaction between epigenetic patterns and genetic or non genetic factors. Several epigenetic mechanisms have been implicated in the regulation of lean NAFLD. These include DNA methylation, histone modifications, and noncoding-RNA-mediated gene regulation. Epigenetics is an area of special interest in the setting of lean NAFLD as it could provide new insights into the therapeutic options and noninvasive biomarkers that target this under-recognized and challenging disorder. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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