Estrous cycle dependent expression of oxycodone conditioned reward in rats.

Autor: Babb JA; Research and Mental Health Services, VA Boston Healthcare System, Boston, Massachusetts, USA. jessica.babb@va.gov.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. jessica.babb@va.gov., Constantino NJ; Division of Basic Neuroscience, McLean Hospital, Belmont, Massachusetts, USA., Kaplan GB; Research and Mental Health Services, VA Boston Healthcare System, Boston, Massachusetts, USA.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.; Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA., Chartoff EH; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.; Division of Basic Neuroscience, McLean Hospital, Belmont, Massachusetts, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Aug 25; Vol. 13 (1), pp. 13946. Date of Electronic Publication: 2023 Aug 25.
DOI: 10.1038/s41598-023-40971-3
Abstrakt: Oxycodone is one of the most widely prescribed and misused opioid painkillers in the United States. Evidence suggests that biological sex and hormonal status can impact drug reward in humans and rodents, but the extent to which these factors can influence the rewarding effects of oxycodone is unclear. The purpose of this study was to utilize place conditioning to determine the effects of sex and female hormonal status on the expression of oxycodone conditioned reward in rats. Gonadally intact adult Sprague-Dawley male and female rats were used to test: (1) whether both sexes express conditioned reward to oxycodone at similar doses, (2) the impact of conditioning session length on oxycodone conditioned reward expression in both sexes, and (3) the influence of female estrous cycle stage on oxycodone conditioned reward expression. Both sexes expressed conditioned reward at the same doses of oxycodone. Increasing the length of conditioning sessions did not reveal an effect of sex and resulted in lower magnitude conditioned reward expression. Importantly however, female stage of estrous cycle significantly influenced oxycodone conditioned reward expression. These results suggest that female hormonal status can impact the rewarding effects of opioids and thus have important implications for prescription opioid treatment practices.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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