Association of lower plasma citric acid with prolonged cough: the Nagahama study.

Autor: Terada S; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Matsumoto H; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. hmatsumoto@med.kindai.ac.jp.; Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kindai University, 377-2 Ohno-Higashi, Osakasayama City, Osaka, Japan. hmatsumoto@med.kindai.ac.jp., Nishi K; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kogo M; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nomura N; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tashima N; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Morimoto C; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Sunadome H; Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nagasaki T; Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Oguma T; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nakatsuka Y; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Murase K; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan., Sonomura K; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Technology Research Laboratory, Life Science Research Center, Shimadzu Corporation, Kyoto, Japan., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Chin K; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Sleep Medicine and Respiratory Care, Division of Sleep Medicine, Nihon University of Medicine, Tokyo, Japan., Hirai T; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Aug 25; Vol. 13 (1), pp. 13921. Date of Electronic Publication: 2023 Aug 25.
DOI: 10.1038/s41598-023-40878-z
Abstrakt: Little is known about the association of prolonged cough, a common and troublesome symptom, with metabolic pathways. We aimed to clarify this association using data from the Nagahama cohort, a prospective study of participants from the general population. Self-report questionnaires on prolonged cough were collected at baseline and 5-year follow-up assessments. Blood tests at follow-up were used for gas chromatography-mass spectrometry-based metabolomics. The association between metabolites and prolonged cough was examined using the partial least squares discriminant analysis and multiple regression analysis. Among the 7432 participants, 632 had newly developed prolonged cough at follow-up, which was defined as "new-onset prolonged cough". Low plasma citric acid was significantly associated with new-onset prolonged cough, even after the adjustment of confounding factors including the presence of asthma, upper airway cough syndrome (UACS), and gastroesophageal reflux disease (GERD). A similar association was observed for isocitric acid, 3-hydroxybutyric acid, and 3-hydroxyisobutyric acid. The analysis of these four metabolites revealed that citric acid had the strongest association with new-onset prolonged cough. This significant association remained even when the analysis was confined to participants with UACS or GERD at baseline or follow-up, and these associations were also observed in participants (n = 976) who had prolonged cough at follow-up regardless of baseline status. In conclusion, low blood citric acid may be associated with prolonged cough.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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