Neural abnormalities of reward processing in adolescents with bipolar disorders: An ERP study.

Autor: Stim JJ; Minneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Twin Cities, USA. Electronic address: snezana.urosevic@gmail.com., Maresh EL; Minneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychology, University of Arizona, USA., Van Voorhis AC; Minneapolis VA Health Care System, Minneapolis, MN, USA., Kang SS; Minneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry, University of Missouri, Kansas City, USA., Luciana M; Department of Psychology, University of Minnesota, Twin Cities, USA., Collins P; Department of Psychology, University of Minnesota, Twin Cities, USA., Sponheim SR; Minneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Twin Cities, USA., Urošević S; Minneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Twin Cities, USA.
Jazyk: angličtina
Zdroj: Biological psychology [Biol Psychol] 2023 Oct; Vol. 183, pp. 108667. Date of Electronic Publication: 2023 Aug 23.
DOI: 10.1016/j.biopsycho.2023.108667
Abstrakt: Adolescent onset is common in bipolar disorders (BDs) and is associated with a worse illness course in adulthood. A model of BDs suggests that a dysregulated behavioral approach system (BAS), a neural system that mobilizes reward-seeking behavior, is at the root of BDs. Normative adolescence is often accompanied by dynamic changes to neural structures underlying the BAS and related cognitive processes. It is possible that adolescent-onset BDs is associated with abnormal BAS neurodevelopment. Consistently, the present study is the first to compare specific BAS-relevant anticipatory and consummatory reward processes as indexed by event-related potentials (ERPs) in adolescents with BDs and typically developing peers. Using a sample of 43 adolescents with BDs and 56 without psychopathology, we analyzed N1 and P3 responses to anticipatory cues and feedback-related negativity (FRN) and P3 responses to feedback stimuli during a monetary incentive delay (MID) task. Hierarchical linear models examined relationships between ERP amplitudes and diagnostic group, MID condition, sex, and age. During anticipation phase, adolescent boys with BDs exhibited significantly larger N1 amplitudes in loss than even or gain trials. During feedback phase, compared to their healthy peers, adolescents with BDs had smaller FRN amplitudes across all conditions. Additional effects involving age, sex and trial type were observed. The findings indicate subtle, non-ubiquitous BAS-relevant neural abnormalities involving early attentional processes during reward anticipation and reward learning following feedback in adolescents with BDs. Adolescents with BDs did not show overall hypersensitive neural responses to monetary reward anticipation or feedback observed in adults with BDs.
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest with respect to their authorship or the publication of this article.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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