Experts Achieve Consensus on a Majority of Statements Regarding Platelet-Rich Plasma Treatments for Treatment of Musculoskeletal Pathology.

Autor:	Hurley ET; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, U.S.A. Electronic address: Eoghan.hurley@duke.edu., Sherman SL; Department of Orthopaedic Surgery, Stanford University, Stanford, California, U.S.A., Stokes DJ; Department of Orthopaedic Surgery, University of Colorado School of Medicine, Aurora, Colorado, U.S.A., Rodeo SA; Hospital for Special Surgery, New York, New York, U.S.A., Shapiro SA; Department of Orthopaedic Surgery, Mayo Clinic, Jacksonville, Florida, U.S.A., Mautner K; Department of Physical Medicine & Rehabilitation, Emory University School of Medicine, Atlanta, Georgia, U.S.A., Buford DA; Texas Orthobiologics, Dallas, Texas, U.S.A., Dragoo JL; Department of Orthopaedic Surgery, University of Colorado School of Medicine, Aurora, Colorado, U.S.A., Mandelbaum BR; Cedars Sinai-Kerlan Jobe Institute, Los Angeles, California, U.S.A.; Clínica Espregueira, FIFA Medical Centre of Excellence, Porto, Portugal., Zaslav KR; Lenox Hill Hospital Northwell Health Orthopedic Institute, New York, New York, U.S.A., Cole BJ; Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, Illinois, U.S.A., Frank RM; Department of Orthopaedic Surgery, University of Colorado School of Medicine, Aurora, Colorado, U.S.A.
Jazyk:	angličtina
Zdroj:	Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association [Arthroscopy] 2024 Feb; Vol. 40 (2), pp. 470-477.e1. Date of Electronic Publication: 2023 Aug 23.
DOI:	10.1016/j.arthro.2023.08.020
Abstrakt:	Purpose: To establish consensus statements on platelet-rich plasma (PRP) for the treatment of musculoskeletal pathologies. Methods: A consensus process on the treatment of PRP using a modified Delphi technique was conducted. Thirty-five orthopaedic surgeons and sports medicine physicians participated in these consensus statements on PRP. The participants were composed of representatives of the Biologic Association, representing 9 international orthopaedic and musculoskeletal professional societies invited due to their active interest in the study of orthobiologics. Consensus was defined as achieving 80% to 89% agreement, strong consensus was defined as 90% to 99% agreement, and unanimous consensus was indicated by 100% agreement with a proposed statement. Results: There was consensus on 62% of statements about PRP. Conclusions: (1) PRP should be classified based on platelet count, leukocyte count, red blood count, activation method, and pure-plasma versus fibrin matrix; (2) PRP characteristics for reporting in research studies are platelet count, leukocyte count, neutrophil count, red blood cell count, total volume, the volume of injection, delivery method, and the number of injections; (3) the prognostic factors for those undergoing PRP injections are age, body mass index, severity/grade of pathology, chronicity of pathology, prior injections and response, primary diagnosis (primary vs postsurgery vs post-trauma vs psoriatic), comorbidities, and smoking; (4) regarding age and body mass index, there is no minimum or maximum, but clinical judgment should be used at extremes of either; (5) the ideal dose of PRP is undetermined; and (6) the minimal volume required is unclear and may depend on the pathology. Level of Evidence: Level V, expert opinion. (Copyright © 2023 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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