Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology.

Autor: Qureshi HM; Department of Neurological Surgery, University of Massachusetts Medical School, Worcester, MA, USA.; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Tabor JK; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Pickens K; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Lei H; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Vasandani S; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Jalal MI; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Vetsa S; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Elsamadicy A; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Marianayagam N; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Theriault BC; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Fulbright RK; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA.; Yale School of Public Health, New Haven, CT, USA., Qin R; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA.; Yale School of Public Health, New Haven, CT, USA., Yan J; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA.; Yale School of Public Health, New Haven, CT, USA., Jin L; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., O'Brien J; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Morales-Valero SF; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA., Moliterno J; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA. jennifer.moliternogunel@yale.edu.; The Chênevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, CT, USA. jennifer.moliternogunel@yale.edu.
Jazyk: angličtina
Zdroj: Journal of neuro-oncology [J Neurooncol] 2023 Sep; Vol. 164 (2), pp. 299-308. Date of Electronic Publication: 2023 Aug 25.
DOI: 10.1007/s11060-023-04416-1
Abstrakt: Purpose: Frailty has gained prominence in neurosurgical oncology, with more studies exploring its relationship to postoperative outcomes in brain tumor patients. As this body of literature continues to grow, concisely reviewing recent developments in the field is necessary. Here we provide a systematic review of frailty in brain tumor patients subdivided by tumor type, incorporating both modern frailty indices and traditional Karnofsky Performance Status (KPS) metrics.
Methods: Systematic literature review was performed using PRISMA guidelines. PubMed and Google Scholar were queried for articles related to frailty, KPS, and brain tumor outcomes. Only articles describing novel associations between frailty or KPS and primary intracranial tumors were included.
Results: After exclusion criteria, systematic review yielded 52 publications. Amongst malignant lesions, 16 studies focused on glioblastoma. Amongst benign tumors, 13 focused on meningiomas, and 6 focused on vestibular schwannomas. Seventeen studies grouped all brain tumor patients together. Seven studies incorporated both frailty indices and KPS into their analyses. Studies correlated frailty with various postoperative outcomes, including complications and mortality.
Conclusion: Our review identified several patterns of overall postsurgical outcomes reporting for patients with brain tumors and frailty. To date, reviews of frailty in patients with brain tumors have been largely limited to certain frailty indices, analyzing all patients together regardless of lesion etiology. Although this technique is beneficial in providing a general overview of frailty's use for brain tumor patients, given each tumor pathology has its own unique etiology, this combined approach potentially neglects key nuances governing frailty's use and prognostic value.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz: