Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections.
| Autor: | Hetta HF; Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt., Ramadan YN; Department of Microbiology and Immunology, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt., Al-Kadmy IMS; Branch of Biotechnology, Department of Biology, College of Science, Mustansiriyah University, Baghdad P.O. Box 10244, Iraq., Ellah NHA; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt.; Department of Pharmaceutics, Faculty of Pharmacy, Badr University in Assiut, Naser City, Assiut 2014101, Egypt., Shbibe L; Faculty of Science, Damascus University, Damascus 97009, Syria., Battah B; Department of Biochemistry and Microbiology, Faculty of Pharmacy, Syrian Private University (SPU), Daraa International Highway, Damascus 36822, Syria. |
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| Jazyk: | angličtina |
| Zdroj: | Pathogens (Basel, Switzerland) [Pathogens] 2023 Aug 13; Vol. 12 (8). Date of Electronic Publication: 2023 Aug 13. |
| DOI: | 10.3390/pathogens12081033 |
| Abstrakt: | An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Additionally, the fungus has become resistant to decontamination techniques and can survive for weeks in a hospital environment. Nanoparticles might be a good substitute to treat illnesses brought on by this newly discovered pathogen. Nanoparticles have become a trend and hot topic in recent years to combat this fatal fungus. This review gives a general insight into the epidemiology of C. auris and infection. It discusses the current conventional therapy and mechanism of resistance development. Furthermore, it focuses on nanoparticles, their different types, and up-to-date trials to evaluate the promising efficacy of nanoparticles with respect to C. auris . |
| Databáze: | MEDLINE |
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