| Autor: |
Szekely J; Faculty of Medical Technology, Prince of Songkla University, Hat Yai, Thailand., Rakchang W; Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Rattanaphan P; Clinical Microbiology Unit, Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand., Kositpantawong N; Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand. |
| Jazyk: |
angličtina |
| Zdroj: |
Epidemiology and infection [Epidemiol Infect] 2023 Aug 25; Vol. 151, pp. e146. Date of Electronic Publication: 2023 Aug 25. |
| DOI: |
10.1017/S0950268823001346 |
| Abstrakt: |
Antifungal susceptibility of Candida species is decreasing. Successful treatment for antifungal-resistant candida infection is challenging and associated with significant mortality. We performed a prospective observational study to identify the species and antifungal susceptibilities of invasive isolates of Candida species over a 5-year period at a university hospital in southern Thailand. Between 2017 and 2021, the species distribution was 39.1% Candida tropicalis , 24.8% Candida albicans , 20.3% Candida parapsilosis complex, 10.5% Candida glabrata , and 5.2% miscellaneous Candida spp. Notable observations include elevated minimal inhibitory concentration (MIC) and decrease susceptibility of C. tropicalis and C. glabrata to echinocandin and all tested triazoles. A shift of MIC 90 value in the COVID-19 era was seen in C. albicans and C. tropicalis with azoles and echinocandins. Azole resistance increased among C. tropicalis isolates, and echinocandin resistance also increased among C. parapsilosis and C. glabrata isolates. Novel alterations in FKS 1 HS1 and HS2 were detected in both isolates of anidulafungin-resistant C. parapsilosis. As Candida species have become more resistant to azoles and less susceptible to echinocandin development, the need arose to observe the emergence of resistance to both antifungal classes in candida clinical isolates, for a more effective infection control in the hospital. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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