Adding New Chemistries to the Central Dogma of Molecular Biology.
| Autor: | Diercks CS; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.; These authors contributed equally., Dik DA; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.; These authors contributed equally., Schultz PG; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.; Lead contact. |
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| Jazyk: | angličtina |
| Zdroj: | Chem [Chem] 2021 Nov 11; Vol. 7 (11), pp. 2883-2895. Date of Electronic Publication: 2021 Oct 22. |
| DOI: | 10.1016/j.chempr.2021.09.014 |
| Abstrakt: | The maturation of chemical synthesis during the 20 th century has elevated the discipline from a largely empirical into a rational science. This ability to purposefully craft matter at the molecular level has put chemists in a privileged position to contribute to progress in neighboring natural sciences. Recently, we have witnessed another major advance in the field in which chemists use chemical and biological "synthetic" methods together to alter the structures and properties of biological macromolecules in ways heretofore unimagined. This interdisciplinary approach to synthesis has even allowed us to expand upon the defining characteristics of living organisms at the molecular level. In this perspective, we present a case study for the successful addition of new chemistries to the fundamental processes of the central dogma of molecular biology, exemplified by the expansion of the genetic code. Competing Interests: DECLARATION OF INTERESTS The authors declare no competing interest. |
| Databáze: | MEDLINE |
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