Flow evaluation software for four-dimensional flow MRI: a reliability and validation study.

Autor: Burkhardt BEU; Paediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children's Hospital Zürich, Steinwiesstrasse 75, 8032, Zurich, Switzerland. barbara.burkhardt@kispi.uzh.ch.; Children's Research Center, University Children's Hospital Zürich, Zurich, Switzerland. barbara.burkhardt@kispi.uzh.ch., Kellenberger CJ; Department of Diagnostic Imaging, University Children's Hospital Zürich, Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zürich, Zurich, Switzerland., Callaghan FM; Department of Diagnostic Imaging, University Children's Hospital Zürich, Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zürich, Zurich, Switzerland., Valsangiacomo Buechel ER; Paediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children's Hospital Zürich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zürich, Zurich, Switzerland., Geiger J; Department of Diagnostic Imaging, University Children's Hospital Zürich, Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zürich, Zurich, Switzerland.
Jazyk: angličtina
Zdroj: La Radiologia medica [Radiol Med] 2023 Oct; Vol. 128 (10), pp. 1225-1235. Date of Electronic Publication: 2023 Aug 24.
DOI: 10.1007/s11547-023-01697-4
Abstrakt: Purpose: Four-dimensional time-resolved phase-contrast cardiovascular magnetic resonance imaging (4D flow MRI) enables blood flow quantification in multiple vessels, which is crucial for patients with congenital heart disease (CHD). We investigated net flow volumes in the ascending aorta and pulmonary arteries by four different postprocessing software packages for 4D flow MRI in comparison with 2D cine phase-contrast measurements (2D PC).
Material and Methods: 4D flow and 2D PC datasets of 47 patients with biventricular CHD (median age 16, range 0.6-52 years) were acquired at 1.5 T. Net flow volumes in the ascending aorta, the main, right, and left pulmonary arteries were measured using four different postprocessing software applications and compared to offset-corrected 2D PC data. Reliability of 4D flow postprocessing software was assessed by Bland-Altman analysis and intraclass correlation coefficient (ICC). Linear regression of internal flow controls was calculated. Interobserver reproducibility was evaluated in 25 patients.
Results: Correlation and agreement of flow volumes were very good for all software compared to 2D PC (ICC ≥ 0.94; bias ≤ 5%). Internal controls were excellent for 2D PC (r ≥ 0.95, p < 0.001) and 4D flow (r ≥ 0.94, p < 0.001) without significant difference of correlation coefficients between methods. Interobserver reliability was good for all vendors (ICC ≥ 0.94, agreement bias < 8%).
Conclusion: Haemodynamic information from 4D flow in the large thoracic arteries assessed by four commercially available postprocessing applications matches routinely performed 2D PC values. Therefore, we consider 4D flow MRI-derived data ready for clinical use in patients with CHD.
(© 2023. The Author(s).)
Databáze: MEDLINE
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