Respiratory Severity Score during the First 3 Hours of Life as a Predictor for Failure of Noninvasive Respiratory Support and Need for Late Rescue Surfactant Administration.
| Autor: | Zapata HA; Division of Neonatology, Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin., Becker HL; Department of Respiratory Therapy, UnityPoint-Meriter, Madison, Wisconsin., Lasarev MR; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin., Fort P; Division of Neonatology, Department of Pediatrics, Johns Hopkins All Children's Hospital, St. Peterburg, Florida., Guthrie SO; Division of Neonatology, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee., Kaluarachchi DC; Division of Neonatology, Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin. |
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| Jazyk: | angličtina |
| Zdroj: | American journal of perinatology [Am J Perinatol] 2024 May; Vol. 41 (S 01), pp. e2613-e2621. Date of Electronic Publication: 2023 Aug 24. |
| DOI: | 10.1055/s-0043-1772747 |
| Abstrakt: | Objective: Preterm infants often develop failure of noninvasive respiratory support. These infants miss the advantages of early rescue surfactant therapy. In this study, we evaluate the utility of respiratory severity score (RSS) during the first 3 hours of life (HOL) as a predictor for failure of noninvasive respiratory support. Study Design: We conducted a post hoc analysis of infants between 23 and 40 weeks' gestational age who received usual care in the AERO-02 clinical trial. Univariate and multivariable logistic regression analysis were used to assess whether the RSS summary measures were associated with the odds of surfactant administration. Results: Study involved 146 infants. Sixty-four infants (45%) received surfactant within the first 72 hours. Administration of surfactant was associated with the mean RSS ( p < 0.01) and the linear trend ( p < 0.01). Conclusion: We demonstrated that RSS during the first 3 HOL can predict failure of noninvasive respiratory support and need for late rescue surfactant administration. Optimal RSS cutoffs for early rescue surfactant therapy need to be determined in large cohort studies. Key Points: · Early recognition of infants at risk of failure of noninvasive ventilation is important to prevent complications.. · It is desirable to identify patients who would benefit from early rescue surfactant treatment.. · RSS in first 3 hours can be used as a predictor of failure of noninvasive respiratory support.. Competing Interests: S.O.G., P.F., and D.C.K. serve as consultants for ONY Biotech. P.F. is also a consultant for Fisher-Paykel and Enalare. (Thieme. All rights reserved.) |
| Databáze: | MEDLINE |
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