Predictors of Cognitive Change in Parkinson Disease: A 2-year Follow-up Study.

Autor:	Gasca-Salas C; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales.; Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III.; University CEU-San Pablo, Madrid, Spain., Duff-Canning S; The Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto., McArthur E; London Health Sciences Centre, London, ON, Canada., Armstrong MJ; Department of Neurology, University of Florida College of Medicine; Gainesville, FL., Fox S; The Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto., Meaney CA; Department of Family and Community Medicine, University of Toronto., Tang-Wai DF; Department of Medicine (Neurology), University of Toronto, University Health Network Memory Clinic., Gill D; Department of Neurology, Rochester Regional Health., Eslinger PJ; Department of Neurology, Penn State Hershey Medical Center, Hershey, PA., Zadikoff C; Department of Neurology, Northwestern University.; AbbVie Inc., North Chicago., Marshall FJ; Department of Neurology, University of Rochester, Rochester, NY., Mapstone M; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL., Chou KL; Departments of Neurology and Neurosurgery., Persad C; Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, MI., Litvan I; Department of Neurosciences, Parkinson and Other Movement Disorders Center UC San Diego, La Jolla, CA., Mast BT; Psychological & Brain Sciences, University of Louisville, Louisville, KY., Gerstenecker AT; Department of Neurology, Division of Neuropsychology, University of Alabama at Birmingham, Birmingham, AL., Weintraub S; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL., Marras C; The Edmond J Safra Program in Parkinson's disease, University Health Network, University of Toronto, Toronto.
Jazyk:	angličtina
Zdroj:	Alzheimer disease and associated disorders [Alzheimer Dis Assoc Disord] 2023 Oct-Dec 01; Vol. 37 (4), pp. 335-342. Date of Electronic Publication: 2023 Aug 22.
DOI:	10.1097/WAD.0000000000000576
Abstrakt:	Background: Mild cognitive impairment is common in Parkinson disease (PD-MCI). However, instability in this clinical diagnosis and variability in rates of progression to dementia raises questions regarding its utility for longitudinal tracking and prediction of cognitive change in PD. We examined baseline neuropsychological test and cognitive diagnosis predictors of cognitive change in PD. Methods: Persons with PD, without dementia PD (N=138) underwent comprehensive neuropsychological assessment at baseline and were followed up to 2 years. Level II Movement Disorder Society criteria for PD-MCI and PD dementia (PDD) were applied annually. Composite global and domain cognitive z -scores were calculated based on a 10-test neuropsychological battery. Results: Baseline diagnosis of PD-MCI was not associated with a change in global cognitive z -scores. Lower baseline attention and higher executive domain z -scores were associated with greater global cognitive z -score worsening regardless of cognitive diagnosis. Worse baseline domain z -scores in the attention and language domains were associated with progression to MCI or PDD, whereas higher baseline scores in all cognitive domains except executive function were associated with clinical and psychometric reversion to "normal" cognition. Conclusions: Lower scores on cognitive tests of attention were predictive of worse global cognition over 2 years of follow-up in PD, and lower baseline attention and language scores were associated with progression to MCI or PDD. However, PD-MCI diagnosis per se was not predictive of cognitive decline over 2 years. The association between higher executive domain z -scores and greater global cognitive worsening is probably a spurious result. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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