International consensus recommendations for the use of prolonged-infusion beta-lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists.

Autor: Hong LT; Loma Linda University School of Pharmacy, Loma Linda, California, USA., Downes KJ; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., FakhriRavari A; Loma Linda University School of Pharmacy, Loma Linda, California, USA., Abdul-Mutakabbir JC; Loma Linda University School of Pharmacy, Loma Linda, California, USA.; Divisions of Clinical Pharmacy and Black Diaspora and African American Studies, University of California San Diego, La Jolla, California, USA., Kuti JL; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA., Jorgensen S; University of Toronto, Toronto, Ontario, Canada., Young DC; University of Utah College of Pharmacy, Salt Lake City, Utah, USA., Alshaer MH; University of Florida College of Pharmacy, Gainesville, Florida, USA., Bassetti M; University of Genoa, Genoa, Italy., Bonomo RA; Cleveland Veteran Affairs Medical Center, Cleveland, Ohio, USA.; Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Case Western Reserve University, Cleveland, Ohio, USA., Gilchrist M; Imperial College Healthcare National Health Services Trust, London, UK., Jang SM; Loma Linda University School of Pharmacy, Loma Linda, California, USA., Lodise T; Albany College of Pharmacy and Health Sciences, Albany, New York, USA., Roberts JA; Faculty of Medicine, University of Queensland Center for Clinical Research, Brisbane, Queensland, Australia.; Herston Infectious Diseases Institute, Metro North Health, Brisbane, Queensland, Australia.; Departments of Pharmacy and Intensive Care, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France., Tängdén T; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Zuppa A; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Scheetz MH; College of Pharmacy, Pharmacometric Center of Excellence, Midwestern University, Downers Grove, Illinois, USA.; Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA.
Jazyk: angličtina
Zdroj: Pharmacotherapy [Pharmacotherapy] 2023 Aug; Vol. 43 (8), pp. 740-777.
DOI: 10.1002/phar.2842
Abstrakt: Intravenous β-lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent tolerability. β-lactams are well established to display time-dependent bactericidal activity, where reductions in bacterial burden are directly associated with the time that free drug concentrations remain above the minimum inhibitory concentration (MIC) of the pathogen during the dosing interval. In an effort to take advantage of these bactericidal characteristics, prolonged (extended and continuous) infusions (PIs) can be applied during the administration of intravenous β-lactams to increase time above the MIC. PI dosing regimens have been implemented worldwide, but implementation is inconsistent. We report consensus therapeutic recommendations for the use of PI β-lactams developed by an expert international panel with representation from clinical pharmacy and medicine. This consensus guideline provides recommendations regarding pharmacokinetic and pharmacodynamic targets, therapeutic drug-monitoring considerations, and the use of PI β-lactam therapy in the following patient populations: severely ill and nonseverely ill adult patients, pediatric patients, and obese patients. These recommendations provide the first consensus guidance for the use of β-lactam therapy administered as PIs and have been reviewed and endorsed by the American College of Clinical Pharmacy (ACCP), the British Society for Antimicrobial Chemotherapy (BSAC), the Cystic Fibrosis Foundation (CFF), the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), the Infectious Diseases Society of America (IDSA), the Society of Critical Care Medicine (SCCM), and the Society of Infectious Diseases Pharmacists (SIDP).
(© 2023 The Authors. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy published by Wiley Periodicals LLC on behalf of Pharmacotherapy Publications, Inc.)
Databáze: MEDLINE
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