Evaluation of the effect of direct-acting antiviral agents on melatonin level and lipid peroxidation in chronic hepatitis C patients.

Autor:	El-Mahdy NA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt., Abou-Saif S; Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt., Abd El Hamid MI; Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Hashem HM; Department of Pharmacy Practice, Faculty of Pharmacy, Sinai University, El-Arish, Egypt., Hammad MA; Department of Clinical Pharmacy, Faculty of Clinical Pharmacy, Al-Baha University, Al-Baha, Saudi Arabia., Abu-Risha SE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2023 Aug 08; Vol. 14, pp. 1128016. Date of Electronic Publication: 2023 Aug 08 (Print Publication: 2023).
DOI:	10.3389/fphar.2023.1128016
Abstrakt:	Background: Oxidative stress and its end products, such as malondialdehyde (MDA) play a leading role in the pathogenesis of hepatitis C. Melatonin is a hormone that helps regulate circadian rhythms, which likely play a role in infectious diseases in terms of susceptibility, clinical expression, and outcome. Objective: The present study was conducted to assess serum malondialdehyde and melatonin levels in patients with chronic hepatitis C infection before and after the intake of direct-acting antivirals. Method: Forty hepatitis C patients were the subjects of this study. While ten healthy volunteers who matched in age and socioeconomic status served as the control subjects. Malondialdehyde and melatonin were assayed in the serum of the three groups, and the results were statistically analyzed. Results: Hepatitis C patients had significantly higher malondialdehyde ( p < 0.001) but significantly lower melatonin ( p < 0.001) as compared to the healthy controls. After 12 weeks of treatment with direct-acting antivirals, the malondialdehyde level decreased significantly ( p < 0.001) and the melatonin level increased significantly ( p < 0.001). A significant negative correlation between malondialdehyde and melatonin was observed. Conclusion : The present findings suggest that treatment of hepatitis C patients with Direct-acting antivirals improves liver function parameters and antioxidant profiles. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 El-Mahdy, Abou-Saif, Abd EL hamid, Hashem, Hammad and Abu-Risha.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu