A cross-sectional study to evaluate hypovitaminosis C prevalence and risk factors in an acute geriatric unit in Lyon, France: the HYPO-VIT-C protocol.

Autor:	Quillon A; Service de médecine gériatrique, Hospices Civils de Lyon, Lyon, France alfred.quillon@chu-lyon.fr.; Faculté de Médecine Lyon-Est, Université Lyon 1, Lyon, France., Guittard L; Pôle Santé Publique, Service Recherche et Epidémiologie cliniques, Hospices Civils de Lyon, Lyon, France.; Research on Healthcare Performance (RESHAPE), Inserm U1290, Université Claude Bernard Lyon 1, Lyon, France., Goldet K; Clinical Research Centre, Ageing, Brain, Fragility - Hôpital des Charpennes, Hospices Civils de Lyon, Villeurbanne, France., Etienne M; Clinical Research Centre, Ageing, Brain, Fragility - Hôpital des Charpennes, Hospices Civils de Lyon, Villeurbanne, France., Blond E; Department of Biochemistry, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.; CarMeN Laboratory - INSERM U1060, INRAE U1397, University Claude Bernard Lyon 1, Pierre-Bénite, France., Nourredine M; Department of biostatistics, Hospices Civils de Lyon, Lyon, France.; Service hospitalo-universitaire de pharmacotoxicologie, Hospices Civils de Lyon, Lyon, France.; Laboratoire de biométrie et biologie évolutive, UMR CNRS 5558, Lyon, France., Martin-Gaujard G; Service de médecine gériatrique, Hospices Civils de Lyon, Lyon, France., Doh S; Service de médecine gériatrique, Hospices Civils de Lyon, Lyon, France.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2023 Aug 23; Vol. 13 (8), pp. e075924. Date of Electronic Publication: 2023 Aug 23.
DOI:	10.1136/bmjopen-2023-075924
Abstrakt:	Introduction: Vitamin C is an essential micronutrient playing crucial roles in human biology. Hypovitaminosis C is defined by a plasmatic ascorbemia below 23 µmol/L and is associated with numerous outcomes such as cardiovascular diseases, cancers or neurocognitive disorders. Numerous risk factors are common among older adults making them particularly susceptible to hypovitaminosis C. These risk factors include reduced vitamin intakes, higher vitamin metabolism related to polypathology, and iatrogeny because of polypharmacy. However, the precise prevalence of hypovitaminosis C and its risk factors are poorly documented within the geriatric population.A better knowledge of hypovitaminosis C prevalence and risk factor may lead to improving the vitamin C status among older people and prevent its consequences. Method and Analysis: To answer these questions, we designed a monocentric cross-sectional study in a population of older hospitalised patients in Lyon, France. A sample size of 385 patients was needed to estimate hypovitaminosis C prevalence. The study was proposed to all eligible patient aged more than 75 years old entering the participating acute geriatric unit. The plasmatic vitamin C status was systematically assessed for participating patients, and variables part of the medical and geriatric evaluation were collected. For patients with severe vitamin C depletion, an oral supplementation and a follow-up phone call were organised to ensure treatment completion and tolerance. Ethics and Dissemination: The protocol has been approved by an independent national ethics committee and meets the methodological requirements. Final outcomes will be published in a peer-reviewed journal and disseminated through conferences. Trial Registration Number: NCT05668663. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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