Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease.
| Autor: | Pulver RL; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.; University of Colorado Alzheimer's and Cognition Center, University of Colorado School of Medicine, Aurora, Colorado, USA., Kronberg E; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA., Medenblik LM; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.; University of Colorado Alzheimer's and Cognition Center, University of Colorado School of Medicine, Aurora, Colorado, USA., Kheyfets VO; Department of Pediatric Critical Care Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA., Ramos AR; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, USA., Toedebusch CD; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA., Sillau SH; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.; University of Colorado Alzheimer's and Cognition Center, University of Colorado School of Medicine, Aurora, Colorado, USA., Bettcher BM; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.; University of Colorado Alzheimer's and Cognition Center, University of Colorado School of Medicine, Aurora, Colorado, USA., Lucey BP; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, USA., McConnell BV; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.; University of Colorado Alzheimer's and Cognition Center, University of Colorado School of Medicine, Aurora, Colorado, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jan; Vol. 20 (1), pp. 301-315. Date of Electronic Publication: 2023 Aug 23. |
| DOI: | 10.1002/alz.13420 |
| Abstrakt: | Introduction: Memory-associated neural circuits produce oscillatory events including theta bursts (TBs), sleep spindles (SPs), and slow waves (SWs) in sleep electroencephalography (EEG). Changes in the "coupling" of these events may indicate early Alzheimer's disease (AD) pathogenesis. Methods: We analyzed 205 aging adults using single-channel sleep EEG, cerebrospinal fluid (CSF) AD biomarkers, and Clinical Dementia Rating® (CDR®) scale. We mapped SW-TB and SW-SP neural circuit coupling precision to amyloid positivity, cognitive impairment, and CSF AD biomarkers. Results: Cognitive impairment correlated with lower TB spectral power in SW-TB coupling. Cognitively unimpaired, amyloid positive individuals demonstrated lower precision in SW-TB and SW-SP coupling compared to amyloid negative individuals. Significant biomarker correlations were found in oscillatory event coupling with CSF Aβ Discussion: Sleep-dependent memory processing integrity in neural circuits can be measured for both SW-TB and SW-SP coupling. This breakdown associates with amyloid positivity, increased AD pathology, and cognitive impairment. Highlights: At-home sleep EEG is a potential biomarker of neural circuits linked to memory. Circuit precision is associated with amyloid positivity in asymptomatic aging adults. Levels of CSF amyloid and tau also correlate with circuit precision in sleep EEG. Theta burst EEG power is decreased in very early mild cognitive impairment. This technique may enable inexpensive wearable EEGs for monitoring brain health. (© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.) |
| Databáze: | MEDLINE |
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