Centrifugation-Assisted Three-Dimensional Printing of Devices Embedded with Fully Enclosed Microchannels.

Autor:	Chu CH; School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Burentugs E; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Lee D; School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Owens JM; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Liu R; School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Frazier AB; School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Sarioglu AF; School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA.; Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, Georgia, USA.
Jazyk:	angličtina
Zdroj:	3D printing and additive manufacturing [3D Print Addit Manuf] 2023 Aug 01; Vol. 10 (4), pp. 609-618. Date of Electronic Publication: 2023 Aug 09.
DOI:	10.1089/3dp.2021.0133
Abstrakt:	The challenges in reliably removing the sacrificial material from fully enclosed microfluidic channels hinder the use of three-dimensional (3D) printing to create microfluidic devices with intricate geometries. With advances in printer resolution, the etching of sacrificial materials from increasingly smaller channels is poised to be a bottleneck using the existing techniques. In this study, we introduce a microfabrication approach that utilizes centrifugation to effortlessly and efficiently remove the sacrificial materials from 3D-printed microfluidic devices with densely packed microfeatures. We characterize the process by measuring the etch rate under different centrifugal forces and developed a theoretical model to estimate process parameters for a given geometry. The effect of the device layout on the centrifugal etching process is also investigated. We demonstrate the applicability of our approach on devices fabricated using inkjet 3D printing and stereolithography. Finally, the advantages of the introduced approach over commonly used injection-based etching of sacrificial material are experimentally demonstrated in direct comparisons. A robust method to postprocess additively manufactured geometries composed of intricate microfluidic channels can help utilize both the large printing volume and high spatial resolution afforded by 3D printing in creating a variety of devices ranging from scaffolds to large-scale microfluidic assays. Competing Interests: There are no conflicts of interest to declare. (Copyright 2023, Mary Ann Liebert, Inc., publishers.)
Databáze:	MEDLINE
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