Hemodynamic responses to handgrip and metaboreflex activation are exaggerated in individuals with metabolic syndrome independent of resting blood pressure, waist circumference, and fasting blood glucose.

Autor:	Stavres J; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS, United States., Aultman RA; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS, United States., Brandner CF; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS, United States., Newsome TA; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS, United States., Vallecillo-Bustos A; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS, United States., Wise HL; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS, United States., Henderson A; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS, United States., Stanfield D; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS, United States., Mannozzi J; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, United States., Graybeal AJ; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2023 Aug 07; Vol. 14, pp. 1212775. Date of Electronic Publication: 2023 Aug 07 (Print Publication: 2023).
DOI:	10.3389/fphys.2023.1212775
Abstrakt:	Introduction: Prior studies report conflicting evidence regarding exercise pressor and metaboreflex responses in individuals with metabolic syndrome (MetS). Purpose: To test the hypotheses that 1) exercise pressor and metaboreflex responses are exaggerated in MetS and 2) these differences may be explained by elevated resting blood pressure. Methods: Blood pressure and heart rate (HR) were evaluated in 26 participants (13 MetS) during 2 min of handgrip exercise followed by 3 min of post-exercise circulatory occlusion (PECO). Systolic (SBP), diastolic (DBP), and mean arterial pressure (MAP), along with HR and a cumulative blood pressure index (BPI), were compared between groups using independent samples t -tests, and analyses of covariance were used to adjust for differences in resting blood pressure, fasting blood glucose (FBG), and waist circumference (WC). Results: ΔSBP (∼78% and ∼54%), ΔMAP (∼67% and ∼55%), and BPI (∼16% and ∼20%) responses were significantly exaggerated in individuals with MetS during handgrip and PECO, respectively (all p ≤ 0.04). ΔDBP, ΔMAP, and BPI responses during handgrip remained significantly different between groups after independently covarying for resting blood pressure ( p < 0.01), and after simultaneously covarying for resting blood pressure, FBG, and WC ( p ≤ 0.03). Likewise, peak SBP, DBP, MAP, and BPI responses during PECO remained significantly different between groups after adjusting for resting blood pressure ( p ≤ 0.03), with peak SBP, MAP, and BPI response remaining different between groups after adjusting for all three covariates simultaneously ( p ≤ 0.04). Conclusion: These data suggest that exercise pressor and metaboreflex responses are significantly exaggerated in MetS independent of differences in resting blood pressure, FBG, or WC. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Stavres, Aultman, Brandner, Newsome, Vallecillo-Bustos, Wise, Henderson, Stanfield, Mannozzi and Graybeal.)
Databáze:	MEDLINE
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