The therapeutic potential of sphingolipids for cardiovascular diseases.

Autor:	Ya'ar Bar S; Department of Natural Compound, Nutrition, and Health, MIGAL, Kiryat Shmona, Israel., Pintel N; Department of Natural Compound, Nutrition, and Health, MIGAL, Kiryat Shmona, Israel., Abd Alghne H; Department of Natural Compound, Nutrition, and Health, MIGAL, Kiryat Shmona, Israel.; Tel-Hai College Department of Biotechnology, Kiryat Shmona, Israel., Khattib H; Department of Natural Compound, Nutrition, and Health, MIGAL, Kiryat Shmona, Israel.; Department of Gastroenterology and Hepatology, Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel., Avni D; Department of Natural Compound, Nutrition, and Health, MIGAL, Kiryat Shmona, Israel.; Tel-Hai College Department of Biotechnology, Kiryat Shmona, Israel.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2023 Aug 07; Vol. 10, pp. 1224743. Date of Electronic Publication: 2023 Aug 07 (Print Publication: 2023).
DOI:	10.3389/fcvm.2023.1224743
Abstrakt:	Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide and Inflammation plays a critical role in the development of CVD. Despite considerable progress in understanding the underlying mechanisms and various treatment options available, significant gaps in therapy necessitate the identification of novel therapeutic targets. Sphingolipids are a family of lipids that have gained attention in recent years as important players in CVDs and the inflammatory processes that underlie their development. As preclinical studies have shown that targeting sphingolipids can modulate inflammation and ameliorate CVDs, targeting sphingolipids has emerged as a promising therapeutic strategy. This review discusses the current understanding of sphingolipids' involvement in inflammation and cardiovascular diseases, the existing therapeutic approaches and gaps in therapy, and explores the potential of sphingolipids-based drugs as a future avenue for CVD treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Ya'ar Bar, Pintel, Abd Alghne, Khattib and Avni.)
Databáze:	MEDLINE
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