Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD-J B study.

Autor: Masaki N; Department of Intensive Care Medicine, National Defense Medical College, Tokorozawa, Japan., Adachi T; Department of Cardiology, National Defense Medical College, Tokorozawa, Japan., Tomiyama H; Department of Cardiology, Tokyo Medical University, Tokyo, Japan., Kohro T; Department of Hospital Planning and Management, Medical Informatics, Jichi Medical University School of Medicine, Tochigi, Japan., Suzuki T; Cardiovascular Medicine, University of Leicester, Leicester, UK., Ishizu T; Cardiovascular Division, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan., Ueda S; Department of Clinical Pharmacology and Therapeutics, University of the Ryukyu School of Medicine, Okinawa, Japan., Yamazaki T; Department of Clinical Epidemiology and Systems, Faculty of Medicine, The University of Tokyo, Tokyo, Japan., Furumoto T; Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan., Kario K; Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Tochigi, Japan., Inoue T; Dokkyo Medical University; Nasu Red Cross Hospital, Tochigi, Japan., Koba S; Department of Medicine, Division of Cardiology, Showa University School of Medicine, Tokyo, Japan., Takemoto Y; Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan., Hano T; Department of Medical Education and Population-based Medicine, Postgraduate School of Medicine, Wakayama Medical University, Wakayama, Japan., Sata M; Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan., Ishibashi Y; Department of General Medicine, Shimane University Faculty of Medicine, Shimane, Japan., Node K; Department of Cardiovascular Medicine, Saga University, Saga, Japan., Maemura K; Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Ohya Y; The Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan., Furukawa T; Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan., Ito H; Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan., Higashi Y; Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan., Yamashina A; Department of Cardiology, Tokyo Medical University, Tokyo, Japan., Takase B; Department of Intensive Care Medicine, National Defense Medical College, Tokorozawa, Japan.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2023 Aug; Vol. 11 (16), pp. e15786.
DOI: 10.14814/phy2.15786
Abstrakt: Type 2 diabetes mellitus (T2DM) is a major cause of microvascular dysfunction. However, its effect on blood flow patterns during ischemic demand has not been adequately elucidated. In this study, we investigated the hypothesis that microvascular dysfunction in patients with T2DM manifests as brachial reactive hyperemia (BRH), defined as the ratio of peak blood flow velocities in a brachial artery before and after forearm cuff occlusion. The study enrolled 943 subjects (men, n = 152 [T2DM] and n = 371 [non-T2DM]; women, n = 107 [T2DM] and n = 313 [non-T2DM], respectively) with no history of cardiovascular disease. Semiautomatic measurements were obtained three times at 1.5-year intervals to confirm the reproducibility of factors involved in BRH for each sex. An age-adjusted mixed model demonstrated attenuated BRH in the presence of T2DM in both men (p = 0.022) and women (p = 0.031) throughout the study period. Post hoc analysis showed that the estimated BRH was significantly attenuated in patients with T2DM regardless of sex, except at baseline in women. In multivariate regression analysis, T2DM was a negative predictor of BRH at every measurement in men. For women, BRH was more strongly associated with alcohol consumption. Repeated measurements analysis revealed that T2DM was associated with attenuated postocclusion reactive hyperemia.
(© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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