Pregnancy Rates in Women With Polycystic Ovary Syndrome (PCOS) Using Letrozole Versus Clomiphene Citrate: A Retrospective Record Review.

Autor:	Bahawi YO; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Radwan EM; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Khouj MA; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Alotaibi RK; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Bajuwaiber NA; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Baghlaf LF; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., AlFaraj WF; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Oraif AM; Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Jul 21; Vol. 15 (7), pp. e42257. Date of Electronic Publication: 2023 Jul 21 (Print Publication: 2023).
DOI:	10.7759/cureus.42257
Abstrakt:	Background and objectives Polycystic ovary syndrome (PCOS) is a prominent cause of anovulation. Thus, this study aimed to compare the pregnancy rates of women with PCOS treated with letrozole (LE) or clomiphene citrate (CC) at King Abdulaziz University Hospital. Patients and methods A retrospective record review was conducted from April 2021 to August 2022 to review 1370 records of women with PCOS from January 2015 to December 2021. Sixty-one patients were included in this analysis. Chi-square tests and independent sample t-tests were used to analyze various associations. Statistical significance was set at P < 0.05. Results Letrozole was associated with a higher pregnancy rate (41.7%) than CC (32.0%). However, this relationship was not statistically significant ( P = .619). Furthermore, patients treated with letrozole required fewer cycles to achieve pregnancy (two cycles compared to three cycles). The different age groups and body mass indexes did not affect the pregnancy rate in either group. Conclusion No significant difference was found between CC and LE in ovulation induction and outcome among PCOS patients. Studies with larger sample sizes and multiple centers should be conducted in Saudi Arabia to obtain more conclusive results, which will eventually lead to changes in guidelines for anovulation treatment in women with PCOS. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Bahawi et al.)
Databáze:	MEDLINE
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