| Autor: |
Taha IM; College Of Medicine, Department of Medicine, Taibah University, Saudi Arabia. itaha@taibahu.edu.sa., Abdu Allah AM; College Of Applied Medical Sciences, Taibah University, Yanbu, Saudi Arabia. azza.abdallah@yahoo.com., El Tarhouny S; Ibn Sina National College for Medical Studies, Kingdom Saudi Arabia. shereeneltarhony@hotmail.com., Sultan I; Ibn Sina National College for Medical Studies, Kingdom Saudi Arabia. intessars2014@gmail.com., Al Nozha O; College Of Medicine, Department of Medicine, Taibah University, Saudi Arabia. ozoghaibi@taibahu.edu.sa., Elyyan MM; Sadat City University, Faculty of Pharmacy, Egypt. mayar.elyan@fop.usc.edu.eg., Elmehallawy G; College Of Medicine, Department of Medicine, Taibah University, Saudi Arabia. gda_salem@icloud.com., Aljohani SAS; College of Medicine, ALrayan College, Saudi Arabia. dr.alerwi@gmail.com., Desouky M; College Of Medicine, Department of Medicine, Taibah University, Saudi Arabia. mahadesouky7@gmail.com., Mohamed RAE; Ibn Sina National College for Medical Studies, Kingdom Saudi Arabia. Dr.rehabomran@yahoo.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2023 Jun 30; Vol. 69 (6), pp. 101-109. Date of Electronic Publication: 2023 Jun 30. |
| DOI: |
10.14715/cmb/2023.69.6.16 |
| Abstrakt: |
Osteopenia and osteoporosis, are prevalent skeletal systemic conditions, cause weaker bones and an increased risk of fragility fractures. This work is aimed to evaluate the relation between bone-remolding markers and genotypes of four single nucleotide polymorphisms in young Saudi females (rs2297480 of farnesyl diphosphate synthase (FDPS), rs3736228 of Low-density lipoprotein receptor-related protein 5 (LRP5), rs1234612 of sclerostin (SOST), and rs9934438 of Vitamin K epoxide reductase complex subunit 1 (VKORC1) ). For this purpose, 750 premenopausal females aged 18 to 40 years old, either university students, postgraduates, or university employees were recruited and divided into three groups according to bone mineral density BMD (g/cm2) divided by T score into osteoporosis (n = 12), osteopenia (n = 147), and normal (n = 591). Serum SOST, BALP, calcium, phosphate, ALP, albumin, beta-CTXs and human VDR levels were determined. TaqMan SNP Genotyping assays were used to genotype four polymorphisms using real-time PCR (applied biosystem). Results showed that BALP, CTX-1 and SOST were significantly higher in the osteoporosis and osteopenia groups than in the normal group. Bone mineral density readings were considerably lower in females with the GG genotype in FDPS rs2297480 and TT genotype in LRP5 rs3736228, which increase the risk for osteopenia by 3. 6-fold and 3. 06-fold than control respectively. Also, females with the TT genotype in LRP5 rs3736228 have decreased average values for Bone Mineral Density. In conclusion, the GG genotype of FDPS rs2297480 and the TT genotype of LRP5 rs3736228 was shown to be strongly associated with osteopenia in young Saudi females with low bone mineral density and SOST levels. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
