Biosensors, Recent Advances in Determination of BDNF and NfL.

Autor: Mobed A; Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Mobeda@tbzmed.ac.ir.; Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran. Mobeda@tbzmed.ac.ir.; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Mobeda@tbzmed.ac.ir.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Mobeda@tbzmed.ac.ir., Charsouei S; Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran. Scharsouei@tbzmed.ac.ir.; Tabriz Neuroscience Research Center (NRSC), Neurology Department, Tabriz University of Medical Sciences, Tabriz, Iran. Scharsouei@tbzmed.ac.ir.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Scharsouei@tbzmed.ac.ir., Yazdani Y; Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Gargari MK; Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Faculty of Medicine, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran., Ahmadalipour A; Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Sadremousavi SR; Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Psychology, East Azarbayjan Science and Research Branch, Islamic Azad University, Tabriz, Iran., Farrahizadeh M; Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; School of Advanced Technologies in Medicine, Iran University of Medical Science, Tehran, Iran., Shahbazi A; Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Neuroscience, Iran University of Medical Sciences, Tehran, Iran., Haghani M; Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Jazyk: angličtina
Zdroj: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2023 Nov; Vol. 43 (8), pp. 3801-3814. Date of Electronic Publication: 2023 Aug 21.
DOI: 10.1007/s10571-023-01401-0
Abstrakt: Key biomarkers such as Brain Derived Neurotrophic Factor (BDNF) and Neurofilament light chain (NfL) play important roles in the development and progression of many neurological diseases, including multiple sclerosis, Alzheimer's disease, and Parkinson's disease. In these clinical conditions, the underlying biomarker processes are markedly heterogeneous. In this context, robust biomarker discovery is of critical importance for screening, early detection, and monitoring of neurological diseases. The difficulty of directly identifying biochemical processes in the central nervous system (CNS) is challenging. In recent years, biomarkers of CNS inflammatory response have been identified in various body fluids such as blood, cerebrospinal fluid, and tears. Furthermore, biotechnology and nanotechnology have facilitated the development of biosensor platforms capable of real-time detection of multiple biomarkers in clinically relevant samples. Biosensing technology is approaching maturity and will be deployed in communities, at which point screening programs and personalized medicine will become a reality. In this multidisciplinary review, our goal is to highlight clinical and current technological advances in the development of multiplex-based solutions for effective diagnosis and monitoring of neuroinflammatory and neurodegenerative diseases. The trend in the detection if BDNF and NfL.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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