Folic acid-conjugated dextran-coated Zn 0.6 Mn 0.4 Fe 2 O 4 nanoparticles as systemically delivered nano heaters with self-regulating temperature for magnetic hyperthermia therapy of liver tumors.

Autor: Soleymani M; Department of Chemical Engineering, Faculty of Engineering, Arak University, Arak, 38156-88349, Iran., Poorkhani A; Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran., Khalighfard S; Research Center on Developing Advanced Technologies, Tehran, Iran., Velashjerdi M; Department of Material Science and Engineering, Faculty of Engineering, Arak University, Arak, 38156-8-8349, Iran., Khori V; Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran., Khodayari S; International Center for Personalized Medicine, Düsseldorf, Germany., Khodayari H; International Center for Personalized Medicine, Düsseldorf, Germany., Dehghan M; Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran., Alborzi N; Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran., Agah S; Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran., Alizadeh AM; Breast Disease Research Center, Cancer Institute, Tehran University of Medical Sciences, P.O.: 1419733141, Tehran, Iran. aalizadeh@sina.tums.ac.ir.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Aug 21; Vol. 13 (1), pp. 13560. Date of Electronic Publication: 2023 Aug 21.
DOI: 10.1038/s41598-023-40627-2
Abstrakt: Successful cancer treatment using magnetic hyperthermia therapy (MHT) strongly depends on biocompatible magnetic nanoparticles (NPs). They can effectively accumulate in tumor tissues after systemic injection and generate heat in the therapeutic temperature range (42-48 °C) by exposure to an AC magnetic field (AMF). For this purpose, folic acid-conjugated dextran-coated Zn 0.6 Mn 0.4 Fe 2 O 4 (FA-Dex-ZMF) NPs were synthesized as smart nano heaters with self-regulating temperatures for MHT of liver tumors. Animal studies on BALB/c mice showed that the prepared NPs did not cause acute toxicity upon administration up to 100 mg kg -1 . Likewise, no significant changes in hematological and biochemical factors were observed. FA-Dex-ZMF NPs were studied by exposing them to different safe AC magnetic fields (f = 150 kHz, H = 6, 8, and 10 kA m -1 ). Calorimetric experiments revealed that the NPs reached the desired temperature range (42-48 °C), which was suitable for MHT. Moreover, the efficacy of FA-Dex-ZMF NPs in MHT of liver tumors was investigated in vivo in liver-tumor-bearing mice. The obtained results revealed that the average volume of tumors in the control group increased 2.2 times during the study period. In contrast, the tumor volume remained almost constant during treatment in the MHT group. The results indicated that folic acid-conjugated dextran-coated Zn 0.6 Mn 0.4 Fe 2 O 4 NPs with self-regulating temperature could be a promising tool for systemically delivered MHT.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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