Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13 C-labelled Z-OMPD.

Autor: Grashei M; Department of Nuclear Medicine, TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, D-81675, Munich, Germany., Wodtke P; Department of Nuclear Medicine, TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, D-81675, Munich, Germany., Skinner JG; Department of Nuclear Medicine, TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, D-81675, Munich, Germany., Sühnel S; Department of Nuclear Medicine, TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, D-81675, Munich, Germany., Setzer N; Department of Nuclear Medicine, TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, D-81675, Munich, Germany., Metzler T; Comparative Experimental Pathology (CEP), Institute of Pathology, School of Medicine, Technical University of Munich, D-81675, Munich, Germany., Gulde S; Institute for Diabetes and Cancer, Helmholtz Zentrum München, D-85764, Neuherberg, Germany., Park M; Department of Biosciences, TUM School of Natural Sciences, Technical University of Munich, D-85748, Garching, Germany., Witt D; Department of Biosciences, TUM School of Natural Sciences, Technical University of Munich, D-85748, Garching, Germany., Mohr H; Institute for Diabetes and Cancer, Helmholtz Zentrum München, D-85764, Neuherberg, Germany., Hundshammer C; Department of Nuclear Medicine, TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, D-81675, Munich, Germany., Strittmatter N; Department of Biosciences, TUM School of Natural Sciences, Technical University of Munich, D-85748, Garching, Germany., Pellegata NS; Institute for Diabetes and Cancer, Helmholtz Zentrum München, D-85764, Neuherberg, Germany.; Department of Biology and Biotechnology, University of Pavia, I-27100, Pavia, Italy., Steiger K; Comparative Experimental Pathology (CEP), Institute of Pathology, School of Medicine, Technical University of Munich, D-81675, Munich, Germany., Schilling F; Department of Nuclear Medicine, TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, D-81675, Munich, Germany. schilling@tum.de.; Munich Institute of Biomedical Engineering, Technical University of Munich, D-85748, Garching, Germany. schilling@tum.de.; German Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany. schilling@tum.de.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Aug 21; Vol. 14 (1), pp. 5060. Date of Electronic Publication: 2023 Aug 21.
DOI: 10.1038/s41467-023-40747-3
Abstrakt: pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5- 13 C 2 ]Z-OMPD as a hyperpolarized extracellular pH and perfusion sensor for MRI which allows to generate a multiparametric fingerprint of renal disease status and to detect local tumor acidification. Exceptional long T 1 of two minutes at 1 T, high pH sensitivity of up to 1.9 ppm per pH unit and suitability of using the C 1 -label as internal frequency reference enables pH imaging in vivo of three pH compartments in healthy rat kidneys. Spectrally selective targeting of both 13 C-resonances enables simultaneous imaging of perfusion and filtration in 3D and pH in 2D within one minute to quantify renal blood flow, glomerular filtration rates and renal pH in healthy and hydronephrotic kidneys with superior sensitivity compared to clinical routine methods. Imaging multiple biomarkers within a single session renders [1,5- 13 C 2 ]Z-OMPD a promising new hyperpolarized agent for oncology and nephrology.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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