Global epidemiologic patterns of oropharyngeal cancer incidence trends.

Autor:	Zumsteg ZS; Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Luu M; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biostatistics and Bioinformatics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Rosenberg PS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Elrod JK; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.; Department of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA, USA., Bray F; Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France., Vaccarella S; Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France., Gay C; Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA., Lu DJ; Department of Radiation Oncology, The Queen's Medical Center, Honolulu, HI, USA., Chen MM; Department of Surgery, Stanford University, Stanford, CA, USA., Chaturvedi AK; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Goodman MT; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Cancer Prevention and Control, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jazyk:	angličtina
Zdroj:	Journal of the National Cancer Institute [J Natl Cancer Inst] 2023 Dec 06; Vol. 115 (12), pp. 1544-1554.
DOI:	10.1093/jnci/djad169
Abstrakt:	Background: The emergence of human papillomavirus (HPV)-positive oropharyngeal cancer and evolving tobacco use patterns have changed the landscape of head and neck cancer epidemiology internationally. We investigated updated trends in oropharyngeal cancer incidence worldwide. Methods: We analyzed cancer incidence data between 1993 and 2012 from 42 countries using the Cancer Incidence in Five Continents database volumes V through XI. Trends in oropharyngeal cancer incidence were compared with oral cavity cancers and lung squamous cell carcinomas using log-linear regression and age period-cohort modeling. Results: In total, 156 567 oropharyngeal cancer, 146 693 oral cavity cancer, and 621 947 lung squamous cell carcinoma patients were included. Oropharyngeal cancer incidence increased (P < .05) in 19 and 23 countries in men and women, respectively. In countries with increasing male oropharyngeal cancer incidence, all but 1 had statistically significant decreases in lung squamous cell carcinoma incidence, and all but 2 had decreasing or nonsignificant net drifts for oral cavity cancer. Increased oropharyngeal cancer incidence was observed both in middle-aged (40-59 years) and older (≥60 years) male cohorts, with strong nonlinear birth cohort effects. In 20 countries where oropharyngeal cancer incidence increased for women and age period-cohort analysis was possible, 13 had negative or nonsignificant lung squamous cell carcinoma net drifts, including 4 countries with higher oropharyngeal cancer net drifts vs both lung squamous cell carcinoma and oral cavity cancer (P < .05 for all comparisons). Conclusions: Increasing oropharyngeal cancer incidence is seen among an expanding array of countries worldwide. In men, increased oropharyngeal cancer is extending to older age groups, likely driven by human papillomavirus-related birth cohort effects. In women, more diverse patterns were observed, suggesting a complex interplay of risks factors varying by country, including several countries where female oropharyngeal cancer increases may be driven by HPV. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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