β_lactam antibiotics against drug addiction: A novel therapeutic option.

Autor: Esmaili-Shahzade-Ali-Akbari P; Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Ghaderi A; Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Hosseini SMM; Department of Internal Medicine, Faculty of Medicine, Azad Ardabil University of Medical Sciences, Ardabil, Iran., Nejat F; Department of Biology and Health Sciences, Meredith College, Raleigh, North Carolina, USA., Saeedi-Mofrad M; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran., Karimi-Houyeh M; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran., Ghattan A; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran., Etemadi A; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran., Rasoulian E; Department of Medical-Surgical Nursing, School of Nursing Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Khezri A; Department of Anesthesia, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Drug development research [Drug Dev Res] 2023 Nov; Vol. 84 (7), pp. 1411-1426. Date of Electronic Publication: 2023 Aug 21.
DOI: 10.1002/ddr.22110
Abstrakt: Drug addiction as a problem for the health of the individual and the society is the result of a complex process in which there is an interaction between brain nuclei and neurotransmitters (such as glutamate). β-lactam antibiotics, due to their enhancing properties on the glutamate transporter glutamate transporter-1, can affect and counteract the addictive mechanisms of drugs through the regulation of extracellular glutamate. Since glutamate is a key neurotransmitter in the development of drug addiction, it seems that β-lactams can be considered as a promising treatment for addiction. However, more research in this field is necessary to identify other mechanisms involved in their effectiveness. This article is a review of the studies conducted on the effect of β-lactam administration in preventing the development of drug addiction, as well as their possible cellular and molecular mechanisms. This review suggests the clinical use of β-lactam antibiotics that have weak antimicrobial properties (such as clavulanic acid) in the treatment of drug dependence.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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