Management of Incidental Uncontrolled Elevation of Intraoperative Blood Pressure: A Comparative Study on Nitroglycerine Versus Dexmedetomidine Infusion.

Autor:	Elsabeeny WY; Department of Anesthesia, Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt., Shehab NN; Department of Anesthesia, Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt., Ibrahim MA; Department of Anesthesia, Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt., El Desouky ED; Department of Epidemiology and Biostatistics, National Cancer Institute, Cairo University, Cairo, Egypt., Abed SM; Department of Anesthesia, Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	Anesthesiology and pain medicine [Anesth Pain Med] 2023 Mar 10; Vol. 13 (2), pp. e134806. Date of Electronic Publication: 2023 Mar 10 (Print Publication: 2023).
DOI:	10.5812/aapm-134806
Abstrakt:	Background: Uncontrolled elevation of intraoperative blood pressure can result in deleterious effects with increased risk of morbidity and mortality. Objectives: We aimed to compare nitroglycerine infusion with dexmedetomidine infusion in controlling accidental intraoperative uncontrolled hypertension. Methods: This comparative study was conducted on 73 hypertensive patients undergoing cancer surgeries who experienced uncontrolled intraoperative hypertension. The data of 38 patients were retrieved from the medical records for the nitroglycerine group and 35 patients were prospectively enrolled for the dexmedetomidine group. Group N received nitroglycerine infusion (0.3 - 1 µg/kg/min), while group D received dexmedetomidine infusion (0.2 - 0.7 µg/kg/h). Results: Both groups were comparable regarding their demographic data and clinical characteristics. Systolic, diastolic, and mean arterial pressure (MAP) values were significantly lower in group N compared to group D during the period between 60 and 120 minutes intraoperatively (P < 0.001). Heart rate values were significantly lower in group D than in group N (P < 0.001). Postoperative sedation scores were better for group D with lower analgesic requirements (P < 0.001). Conclusions: Dexmedetomidine infusion can be used to manage the uncontrolled intraoperative elevation of blood pressure in selected patient population. Competing Interests: Conflict of Interests: The authors have no personal financial interests. (Copyright © 2023, Author(s).)
Databáze:	MEDLINE
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