Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait.

Autor: Gomes ICP; Health Sciences Graduate Program Federal University of Sergipe Aracaju Sergipe Brazil.; Department of Medicine Federal University of Sergipe Aracaju Sergipe Brazil.; Department of Medicine Tiradentes University Aracaju Sergipe Brazil., Magalhães LS; Health Sciences Graduate Program Federal University of Sergipe Aracaju Sergipe Brazil.; Laboratory of Molecular Biology and Immunology Federal University of Sergipe Aracaju Sergipe Brazil.; Sector of Parasitology and Pathology Biological and Health Sciences Institute Federal University of Alagoas Maceió Alagoas Brazil., Bomfim LGS; Health Sciences Graduate Program Federal University of Sergipe Aracaju Sergipe Brazil., Dos Santos PL; Health Sciences Graduate Program Federal University of Sergipe Aracaju Sergipe Brazil.; Laboratory of Molecular Biology and Immunology Federal University of Sergipe Aracaju Sergipe Brazil.; Department of Health Education Federal University of Sergipe Lagarto Sergipe Brazil., Silva RJDS; Department of Physical Education Federal University of Sergipe, São Cristóvão, Sergipe, Brazil São Cristóvão Sergipe Brazil., Cruz MCP; Health Sciences Graduate Program Federal University of Sergipe Aracaju Sergipe Brazil.; Department of Nutrition Federal University of Sergipe Lagarto Sergipe Brazil., de Albuquerque LC; Department of Medicine Tiradentes University Aracaju Sergipe Brazil., Neves VHD; Department of Medicine Tiradentes University Aracaju Sergipe Brazil., de Oliveira PGPR; Department of Nutrition Federal University of Sergipe Lagarto Sergipe Brazil., Carvalho AF; Department of Nutrition Tiradentes University Aracaju Sergipe Brazil., Silva LO; Department of Medicine Federal University of Sergipe Aracaju Sergipe Brazil., Aragão MT; Health Sciences Graduate Program Federal University of Sergipe Aracaju Sergipe Brazil., Moura TR; Health Sciences Graduate Program Federal University of Sergipe Aracaju Sergipe Brazil.; Department of Morphology Federal University of Sergipe São Cristóvão Sergipe Brazil.; Sector of Parasitology and Pathology Biological and Health Sciences Institute Federal University of Alagoas Maceió Alagoas Brazil., Cipolotti R; Health Sciences Graduate Program Federal University of Sergipe Aracaju Sergipe Brazil.; Department of Medicine Federal University of Sergipe Aracaju Sergipe Brazil.
Jazyk: angličtina
Zdroj: EJHaem [EJHaem] 2023 May 26; Vol. 4 (3), pp. 705-709. Date of Electronic Publication: 2023 May 26 (Print Publication: 2023).
DOI: 10.1002/jha2.712
Abstrakt: Although sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross-sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher levels of lactato dehydrogenase, IL-1β, IL-6, IL-10, and tumor necrosis factor alpha than the others, while the SCT group had similar levels to control group. In addition, SCA group had lower IL-8/IL-10 and soluble triggering receptor expressed on myeloid cells-1/IL-10 ratios. These findings indicate that individuals with SCT do not have a chronic inflammatory profile and reinforce that cytokines are involved in the maintenance of the inflammatory state in SCA.
Competing Interests: The authors declare that they have no conflict of interest.
(© 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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