Plasma AGE and Oxidation Products, Renal Function, and Preeclampsia in Pregnant Women with Type 1 Diabetes: A Prospective Observational Study.

Autor: Kelly CB; Division of Endocrinology, Medical University of South Carolina, Charleston, South Carolina, USA.; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Karanchi H; Division of Endocrinology, Medical University of South Carolina, Charleston, South Carolina, USA., Yu JY; Division of Endocrinology, Medical University of South Carolina, Charleston, South Carolina, USA., Leyva MJ; Division of Endocrinology, Medical University of South Carolina, Charleston, South Carolina, USA.; Diabetes Free South Carolina, BlueCross BlueShield of South Carolina, Columbia, South Carolina, USA., Jenkins AJ; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia., Nankervis AJ; Diabetes Service, The Royal Women's Hospital, Melbourne, VIC, Australia., Hanssen KF; Department of Endocrinology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Garg SK; Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, Colorado, USA., Scardo JA; Spartanburg Regional Medical Center, Spartanburg, South Carolina, USA., Hammad SM; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Aston CE; Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Beisswenger PJ; PreventAGE Health Care, Lebanon, NH, USA., Lyons TJ; Division of Endocrinology, Medical University of South Carolina, Charleston, South Carolina, USA.; Diabetes Free South Carolina, BlueCross BlueShield of South Carolina, Columbia, South Carolina, USA.
Jazyk: angličtina
Zdroj: Journal of diabetes research [J Diabetes Res] 2023 Aug 10; Vol. 2023, pp. 8537693. Date of Electronic Publication: 2023 Aug 10 (Print Publication: 2023).
DOI: 10.1155/2023/8537693
Abstrakt: Aims: We aimed to determine whether plasma advanced glycation end products or oxidation products (AGE/oxidation-P) predict altered renal function and/or preeclampsia (PE) in pregnant women with type 1 diabetes.
Methods: Prospectively, using a nested case-control design, we studied 47 pregnant women with type 1 diabetes, of whom 23 developed PE and 24 did not. Nineteen nondiabetic, normotensive pregnant women provided reference values. In plasma obtained at ~12, 22, and 32 weeks' gestation (visits 1, 2, and 3; V1-V3), we measured five AGE products (carboxymethyllysine (CML), carboxyethyl-lysine (CEL), methylglyoxal-hydroimidazolone (MGH1), 3-deoxyglucosone hydroimidazolone (3DGH), and glyoxal-hydroimidazolone (GH1)) and four oxidation products (methionine sulfoxide (MetSO), 2-aminoadipic acid (2-AAA), 3-nitrotyrosine (3NT), and dityrosine (DT)), by liquid chromatography/mass spectroscopy. Clinical outcomes were "estimated glomerular filtration rate" (eGFR) at each visit and onset of PE.
Results: In diabetic women, associations between AGE/oxidation-P and eGFR were found only in those who developed PE. In this group, CEL, MGH1, and GH1 at V2 and CML, CEL, MGH1, and GH1 at V3 were inversely associated with contemporaneous eGFR, while CEL, MGH1, 3DGH, and GH1 at V2 were inversely associated with eGFR at V3 (all p < 0.05). There were no associations of plasma AGE or oxidation-P with pregnancy-related development of proteinuria or PE.
Conclusions: Inverse associations of second and early third trimester plasma AGE with eGFR among type 1 diabetic women who developed PE suggest that these patients constitute a subset susceptible to AGE-mediated injury and thus to cardiorenal complications later in life. However, AGE/oxidation-P did not predict PE in type 1 diabetic women.
Competing Interests: The authors have declared that no conflict of interest exists.
(Copyright © 2023 Clare B. Kelly et al.)
Databáze: MEDLINE
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