Assessment of clinical characteristics and viral load in individuals infected by Delta and Omicron variants of SARS-CoV-2.

Autor:	Nunes SLP; Postgraduate Program in Applied Cellular and Molecular Biology, University of Pernambuco (UPE), Recife, Pernambuco, Brazil., de França CA; Multi-User Research Laboratory (LAMUPE), Dr. Washington Antônio de Barros Hospital - EBSERH/UNIVASF, Petrolina, Pernambuco, Brazil., Rocha GD; Postgraduate Program in Applied Cellular and Molecular Biology, University of Pernambuco (UPE), Recife, Pernambuco, Brazil.; Multi-User Research Laboratory (LAMUPE), Dr. Washington Antônio de Barros Hospital - EBSERH/UNIVASF, Petrolina, Pernambuco, Brazil., Oliveira SAS; Multi-User Research Laboratory (LAMUPE), Dr. Washington Antônio de Barros Hospital - EBSERH/UNIVASF, Petrolina, Pernambuco, Brazil., Freitas MR; Multi-User Research Laboratory (LAMUPE), Dr. Washington Antônio de Barros Hospital - EBSERH/UNIVASF, Petrolina, Pernambuco, Brazil., da Silva EO; VIII Regional Health Management, State Health Secretariat of Pernambuco, Petrolina, Pernambuco, Brazil., Coutinho KS; VIII Regional Health Management, State Health Secretariat of Pernambuco, Petrolina, Pernambuco, Brazil., Jerônimo AS; VIII Regional Health Management, State Health Secretariat of Pernambuco, Petrolina, Pernambuco, Brazil., de Lima GB; Technology Platforms Center (NPT), Aggeu Magalhães Institute (IAM), FIOCRUZ-Pernambuco, Recife, Pernambuco, Brazil., de Lima RE; Technology Platforms Center (NPT), Aggeu Magalhães Institute (IAM), FIOCRUZ-Pernambuco, Recife, Pernambuco, Brazil., Bezerra MF; Departament of Microbiology, Aggeu Magalhães Institute (IAM), FIOCRUZ-Pernambuco, Recife, Pernambuco, Brazil., Dezordi FZ; Departament of Entomology, Aggeu Magalhães Institute (IAM)- FIOCRUZ-Pernambuco, Recife, Pernambuco, Brazil.; Bioinformatics Center (NBI), Aggeu Magalhães Institute (IAM), FIOCRUZ-Pernambuco, Recife, Pernambuco, Brazil., Paiva MHS; Departament of Entomology, Aggeu Magalhães Institute (IAM)- FIOCRUZ-Pernambuco, Recife, Pernambuco, Brazil.; Life Sciences Center, Federal University of Pernambuco (UFPE), Caruaru, Pernambuco, Brazil., Wallau GDL; Departament of Entomology, Aggeu Magalhães Institute (IAM)- FIOCRUZ-Pernambuco, Recife, Pernambuco, Brazil.; Bioinformatics Center (NBI), Aggeu Magalhães Institute (IAM), FIOCRUZ-Pernambuco, Recife, Pernambuco, Brazil.; Department of Arbovirology, Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany., de Souza CDF; Collegiate of Medicine, Federal University of the São Francisco Valley - UNIVASF, Petrolina, Pernambuco, Brazil., Armstrong ADC; Collegiate of Medicine, Federal University of the São Francisco Valley - UNIVASF, Petrolina, Pernambuco, Brazil., do Carmo RF; Postgraduate Program in Applied Cellular and Molecular Biology, University of Pernambuco (UPE), Recife, Pernambuco, Brazil.; Collegiate of Pharmaceutical Sciences, Federal University of the São Francisco Valley - UNIVASF, Petrolina, Pernambuco, Brazil.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Aug 06; Vol. 9 (8), pp. e18994. Date of Electronic Publication: 2023 Aug 06 (Print Publication: 2023).
DOI:	10.1016/j.heliyon.2023.e18994
Abstrakt:	In late 2021, a new variant of SARS-CoV-2 called Omicron emerged, replacing Delta worldwide. Although it has been associated with a lower risk of hospitalization and severe forms of COVID-19, there is little evidence of its relationship with specific symptoms and viral load. The aim of this study was to verify the relationship between Delta and Omicron variants of concern, viral load, and the occurrence of symptoms in individuals with COVID-19. Nasopharyngeal swab samples were collected and sequenced from patients with COVID-19 from the Northeast Region of Brazil between August 2021 and March 2022. The results showed a gradual replacement of the Delta variant by the Omicron variant during the study period. A total of 316 samples (157 Delta and 159 Omicron) were included. There was a higher prevalence of symptoms in Delta-infected individuals, such as coryza, olfactory and taste disturbances, headache, and myalgia. There was no association between viral load and the variants analyzed. The results reported here contribute to the understanding of the symptoms associated with the Delta and Omicron variants in individuals affected by COVID-19. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Rodrigo Feliciano do Carmo reports financial support was provided by Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). Associate Editor of Heliyon - Rodrigo Feliciano do Carmo. (© 2023 The Authors. Published by Elsevier Ltd.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu