Possible neglected transient (T) polyagglutination in critically ill patients with coronavirus disease-2019 (Covid-19).

Autor: Gasim Dobie -; Department of Medical Laboratory Technology, Jazan University, Gizan, Saudi Arabia., Hassan A Hamali -; Department of Medical Laboratory Technology, Jazan University, Gizan, Saudi Arabia., Abdullah A Mobarki -; Department of Medical Laboratory Technology, Jazan University, Gizan, Saudi Arabia., Muhammad Saboor -; Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, UAE., Mohammad S Akhter -; Department of Medical Laboratory Technology, Jazan University, Gizan, Saudi Arabia., Khaled Essawi Abdulrahim R Hakami -; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha Saudi Arabia., Mohammed H Nahari -; Department of Medical Laboratory Technology, Najran University, Najran, Saudi Arabia., Mohamed A Kolaiby -; Department of Hematology and Blood Bank, Sabya General Hospital, Gizan, Saudi Arabia., Yahya H Matari -; Department of Hematology and Blood Bank, Baish General Hospital, Gizan, Saudi Arabia., Essa Atafi -; Department of Hematology and Blood Bank, Baish General Hospital, Gizan, Saudi Arabia., Ghalib Ghubiri -; Department of Hematology and Blood Bank, Baish General Hospital, Gizan, Saudi Arabia., Abdulrahman A Alhamzi -; Department of Hematology and Blood Bank, King Fahd Central Hospital, Gizan, Saudi Arabia., Abdulrhman Alhamzi -; Department of Planning and Development, King Fahd Central Hospital, Gizan, Saudi Arabia., Amr J Halawani -; Deaprtment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia., Abdullah Hamadi -; Department of Medical Laboratory Technology, Tabuk University, Tabuk, Saudi Arabia., Denise E Jackson -; Thrombosis and Vascular Diseases Laboratory, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC, Austra.
Jazyk: angličtina
Zdroj: Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2023 Jul; Vol. 36 (4), pp. 1211-1215.
Abstrakt: T-activation polyagglutination can be caused by bacteria or viruses and has been associated with haemolytic anaemia. Coronavirus disease-19 (COVID-19) is also associated with haemolytic anaemia. The presented study aims to determine T activation polyagglutination in critically ill COVID-19 patients. Anti-T Arachis hypogaea lectin was incubated with the red blood cells of the COVID-19 patient and checked for agglutination. Thirty-four percent (34.3%) of COVID-19 patients in the intensive care unit (ICU) had potentially activated T cells and polyagglutinable red blood cells, as demonstrated by their cryptantigen exposure that caused agglutination. The study revealed a high prevalence of anti-T among ICU-admitted COVID-19 patients, suggesting that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause transient T activation, polyagglutination in critically ill COVID-19 patients in vitro and possibly haemolysis in vivo.
Databáze: MEDLINE