The Effects of Vitamin D on Markers of Glucose and Obesity in Postmenopausal Women: A Meta-analysis of Randomized Controlled Trials.

Autor: Hao L; Clinical Chinese Medicine Teaching and Research Office, Hebei University of Chinese Medicine, Shijiazhuang, China., Lu A; Clinical Chinese Medicine Teaching and Research Office, Hebei University of Chinese Medicine, Shijiazhuang, China., Gao H; Department of 2nd Nephrology, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang, China., Niu J; Department of Acupuncture, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China., Prabahar K; Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia., Seraj SS; Department of Surgery, Royal Shrewsbury Hospital, Shrewsbury and Telford NHS Trust, Shrewsbury, West Midlands, United Kingdom., Pan Y; Huang Di Neijing Teaching and Research Office, Hebei University of Chinese Medicine, Shijiazhuang, China. Electronic address: panyongmei2023@sina.com.
Jazyk: angličtina
Zdroj: Clinical therapeutics [Clin Ther] 2023 Sep; Vol. 45 (9), pp. 913-920. Date of Electronic Publication: 2023 Aug 17.
DOI: 10.1016/j.clinthera.2023.07.009
Abstrakt: Purpose: The effect of vitamin D effect on glucose markers and obesity in postmenopausal women remains controversial. The current literature contains little information on vitamin D dosage and duration for optimal efficacy in postmenopausal women. This meta-analysis was undertaken to assess the impact of vitamin D on glucose markers and obesity in postmenopausal women.
Methods: A number of databases were used dated up to January 5, 2023, with no language restrictions (PubMed/MEDLINE, Web of Science, EMBASE, and Scopus). Treatment response from baseline was estimated from the mean within-group analysis, and SDs were used to calculate the treatment response.
Findings: Nine eligible articles with 12 comparisons qualified for the final quantitative analysis. An overall decrease was noted in fasting blood glucose (weighted mean difference [WMD], -3.56 mg/dL; 95% CI, -5.49 to -1.64; P < 0.001), homeostatic model assessment for insulin resistance (WMD, -1.168 mm; 95% CI, -2.001 to -0.33; P = 0.006), insulin (WMD, -2.26 units; 95% CI, -4.35 to -0.18; P = 0.033), and glycosylated hemoglobin (WMD, -0.41%; 95% CI, -0.54 to -0.29; P < 0.001) after vitamin D administration in postmenopausal women. In subgroup analyses, a notable decrease in fasting blood glucose was detected when the intervention course was ˃6 months and dosage ≤1000 IU/d (WMD, -3.48 mg/dL). The present study showed that vitamin D was not associated with body mass index, body weight, or waist circumference in postmenopausal women.
Implications: Vitamin D is beneficial for glucose markers but not obesity in postmenopausal women. An individualized dosage regimen of vitamin D should be followed depending on the clinical outcome target of postmenopausal women.
Competing Interests: Declaration of Competing Interest None declared.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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