Effects of repetitive pinprick stimulation on preterm offspring: Alterations in nociceptive responses and inflammatory hypersensitivity in adulthood.

Autor: de Carvalho RC; Postgraduate Program in Biosciences Applied to Health (PPGB), UNIFAL, Alfenas, MG, Brazil; Laboratory of Neuroscience, Neuromodulation and Study of Pain (LANNED), UNIFAL-MG, Alfenas, MG, Brazil., Generoso LP; Postgraduate Program in Biosciences Applied to Health (PPGB), UNIFAL, Alfenas, MG, Brazil; Laboratory of Neuroscience, Neuromodulation and Study of Pain (LANNED), UNIFAL-MG, Alfenas, MG, Brazil., da Silva AL; Graduation in Physiotherapy at the Motricity Sciences Institute, UNIFAL, Alfenas, MG, Brazil; Laboratory of Neuroscience, Neuromodulation and Study of Pain (LANNED), UNIFAL-MG, Alfenas, MG, Brazil., Pereira GS; Graduation in Physiotherapy at the Motricity Sciences Institute, UNIFAL, Alfenas, MG, Brazil; Laboratory of Neuroscience, Neuromodulation and Study of Pain (LANNED), UNIFAL-MG, Alfenas, MG, Brazil., de Paula DC; Graduation in Physiotherapy at the Motricity Sciences Institute, UNIFAL, Alfenas, MG, Brazil; Laboratory of Neuroscience, Neuromodulation and Study of Pain (LANNED), UNIFAL-MG, Alfenas, MG, Brazil., Candido NL; Postgraduate Program in Biosciences Applied to Health (PPGB), UNIFAL, Alfenas, MG, Brazil; Laboratory of Neuroscience, Neuromodulation and Study of Pain (LANNED), UNIFAL-MG, Alfenas, MG, Brazil., Capello MGM; Postgraduate Program in Biosciences Applied to Health (PPGB), UNIFAL, Alfenas, MG, Brazil; Laboratory of Neuroscience, Neuromodulation and Study of Pain (LANNED), UNIFAL-MG, Alfenas, MG, Brazil., da Silva JRT; Laboratory of Neuroscience, Neuromodulation and Study of Pain (LANNED), UNIFAL-MG, Alfenas, MG, Brazil., da Silva ML; Laboratory of Neuroscience, Neuromodulation and Study of Pain (LANNED), UNIFAL-MG, Alfenas, MG, Brazil. Electronic address: marcelo.lourenco@unifal-mg.edu.br.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2023 Oct 02; Vol. 454, pp. 114633. Date of Electronic Publication: 2023 Aug 18.
DOI: 10.1016/j.bbr.2023.114633
Abstrakt: Introduction: This study investigates the effects of repetitive pinprick stimulation on preterm offspring and its impact on nociceptive responses and inflammatory hypersensitivity in adulthood.
Objectives: The objective is to shed light on the potential long-term consequences of neonatal pain and prematurity on sensory processing.
Methods: Term and preterm rats were subjected to repetitive pinprick (PP) stimulation or control (CC) during the neonatal period. Adult rats received CFA injection to induce inflammatory hypersensitivity, and mechanical hypersensitivity was measured. Gender differences in inflammatory hypersensitivity were also examined. Maternal behavior, litter weight, and offspring growth were monitored to assess any potential influences of the stimulation on these parameters.
Results: In preterm rats, the PP stimulation did not affect baseline thresholds to mechanical stimuli, but increased mechanical hypersensitivity after CFA injection in adult rats. Females exhibited greater inflammatory hypersensitivity compared to males. Maternal behavior, litter weight, and offspring growth were not influenced by the stimulation. PP stimulation during the neonatal period led to changes in nociceptive responses in adulthood, potentially altering sensory processing.
Conclusion: PP stimulation in preterm rats during the neonatal period resulted in changes in nociceptive responses in adulthood, leading to increased inflammatory hypersensitivity. The study emphasizes how early development can significantly impact sensory processing and further highlights the potential long-term consequences of prematurity and neonatal pain on this processing.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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