Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia-Data From a Multicenter Randomized-Controlled Study.

Autor:	Roell L; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Neuroimaging Core Unit Munich (NICUM), University Hospital, LMU Munich, Munich, Germany., Keeser D; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Neuroimaging Core Unit Munich (NICUM), University Hospital, LMU Munich, Munich, Germany.; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Papazov B; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Lembeck M; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Papazova I; Department of Psychiatry, Psychotherapy and Psychosomatics of the University Augsburg, Medical Faculty, University of Augsburg, Bezirkskrankenhaus Augsburg, Augsburg, Germany., Greska D; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Muenz S; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Schneider-Axmann T; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Sykorova EB; Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany., Thieme CE; Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany., Vogel BO; Department of Psychiatry and Psychotherapy, University Hospital Charité Berlin, Berlin, Germany., Mohnke S; Department of Psychiatry and Psychotherapy, University Hospital Charité Berlin, Berlin, Germany., Huppertz C; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany., Roeh A; Department of Psychiatry, Psychotherapy and Psychosomatics of the University Augsburg, Medical Faculty, University of Augsburg, Bezirkskrankenhaus Augsburg, Augsburg, Germany., Keller-Varady K; Hannover Medical School, Department of Rehabilitation and Sports Medicine, Hannover, Germany., Malchow B; Department of Psychiatry and Psychotherapy, University Hospital Göttingen, Göttingen, Germany., Stoecklein S; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Ertl-Wagner B; Department of Radiology, University Hospital, LMU Munich, Munich, Germany.; Division of Neuroradiology, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada.; Department of Medical Imaging, University of Toronto, Toronto, Canada., Henkel K; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany., Wolfarth B; Department of Sports Medicine, University Hospital Charité Berlin, Berlin, Germany., Tantchik W; Department of Psychiatry and Psychotherapy, University Hospital Charité Berlin, Berlin, Germany., Walter H; Department of Psychiatry and Psychotherapy, University Hospital Charité Berlin, Berlin, Germany., Hirjak D; Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany., Schmitt A; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of Sao Paulo, São Paulo, Brazil., Hasan A; Department of Psychiatry, Psychotherapy and Psychosomatics of the University Augsburg, Medical Faculty, University of Augsburg, Bezirkskrankenhaus Augsburg, Augsburg, Germany., Meyer-Lindenberg A; Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany., Falkai P; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany., Maurus I; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Jazyk:	angličtina
Zdroj:	Schizophrenia bulletin [Schizophr Bull] 2024 Jan 01; Vol. 50 (1), pp. 145-156.
DOI:	10.1093/schbul/sbad113
Abstrakt:	Background and Hypothesis: Aerobic exercise interventions in people with schizophrenia have been demonstrated to improve clinical outcomes, but findings regarding the underlying neural mechanisms are limited and mainly focus on the hippocampal formation. Therefore, we conducted a global exploratory analysis of structural and functional neural adaptations after exercise and explored their clinical implications. Study Design: In this randomized controlled trial, structural and functional MRI data were available for 91 patients with schizophrenia who performed either aerobic exercise on a bicycle ergometer or underwent a flexibility, strengthening, and balance training as control group. We analyzed clinical and neuroimaging data before and after 6 months of regular exercise. Bayesian linear mixed models and Bayesian logistic regressions were calculated to evaluate effects of exercise on multiple neural outcomes and their potential clinical relevance. Study Results: Our results indicated that aerobic exercise in people with schizophrenia led to structural and functional adaptations mainly within the default-mode network, the cortico-striato-pallido-thalamo-cortical loop, and the cerebello-thalamo-cortical pathway. We further observed that volume increases in the right posterior cingulate gyrus as a central node of the default-mode network were linked to improvements in disorder severity. Conclusions: These exploratory findings suggest a positive impact of aerobic exercise on 3 cerebral networks that are involved in the pathophysiology of schizophrenia. Clinical Trials Registration: The underlying study of this manuscript was registered in the International Clinical Trials Database, ClinicalTrials.gov (NCT number: NCT03466112, https://clinicaltrials.gov/ct2/show/NCT03466112?term=NCT03466112&draw=2&rank=1) and in the German Clinical Trials Register (DRKS-ID: DRKS00009804). (© The Author(s) 2023. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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