Drug-resistant epilepsy: Definition, pathophysiology, and management.

Autor: Mesraoua B; Neurosciences Department, Hamad Medical Corporation and Weill Cornell Medical College, Doha, Qatar. Electronic address: boulenouar.mesraoua@wanadoo.fr., Brigo F; Department of Neurology, Hospital of Merano (SABES-ASDAA), Merano-Meran, Italy., Lattanzi S; Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy., Abou-Khalil B; Vanderbilt University Department of Neurology, Nashville, TN, USA. Electronic address: bassel.abou-khalil@vumc.org., Al Hail H; Neurosciences Department, Hamad Medical Corporation and Weill Cornell Medical College, Doha, Qatar. Electronic address: halhail1@hamad.qa., Asadi-Pooya AA; Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
Jazyk: angličtina
Zdroj: Journal of the neurological sciences [J Neurol Sci] 2023 Sep 15; Vol. 452, pp. 120766. Date of Electronic Publication: 2023 Aug 14.
DOI: 10.1016/j.jns.2023.120766
Abstrakt: There are currently >51 million people with epilepsy (PWE) in the world and every year >4.9 million people develop new-onset epilepsy. The cornerstone of treatment in PWE is drug therapy with antiseizure medications (ASMs). However, about one-third of PWE do not achieve seizure control and do not respond well to drug therapy despite the use of appropriate ASMs [drug-resistant epilepsy (DRE)]. The aims of the current narrative review are to discuss the definition of DRE, explain the biological underpinnings and clinical biomarkers of this condition, and finally to suggest practical management strategies to tackle this issue appropriately, in a concise manner.
Competing Interests: Declaration of competing interest No funding was received for this review. This review was presented at the 5th Qatar International Epilepsy Course in January 12th, 2023 by the authors. We thank Hamad Medical Corporation, Neurosciences and Medical Education Departments for supporting this event.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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