Prevalence of ictal injuries in functional (psychogenic nonepileptic) seizures: A systematic review and meta-analysis.

Autor: Moreira AB; Universidade Federal de Santa Catarina, Florianópolis, Brazil., Knochenhauer AE; Universidade Federal de Santa Catarina, Florianópolis, Brazil., Froehner GV; Universidade Federal de Santa Catarina, Florianópolis, Brazil., Schwarzbold ML; Universidade Federal de Santa Catarina, Florianópolis, Brazil., Asadi-Pooya AA; Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Pennsylvania, Philadelphia, USA., Demarchi IG; Universidade Federal de Santa Catarina, Florianópolis, Brazil., Brigo F; Department of Neurology, Hospital of Merano, Merano, Italy.; Innovation, Research and Teaching Service, Bolzano-Bozen, Italy., Lin K; Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Jazyk: angličtina
Zdroj: Epilepsia [Epilepsia] 2023 Nov; Vol. 64 (11), pp. 3082-3098. Date of Electronic Publication: 2023 Sep 11.
DOI: 10.1111/epi.17752
Abstrakt: Objective: Ictal injuries have long been considered typical signs of epileptic seizures. However, studies have shown that patients with functional seizures (FS)-also named psychogenic nonepileptic seizures-can also present these signs, misleading physicians and delaying a correct diagnosis. This systematic review aimed to assess the prevalence of injuries from FS.
Methods: A literature search was performed in PubMed, Embase, LILACS (Latin American and Caribbean Health Sciences Literature), Scopus, Web of Science, PsycINFO, Google Scholar, OpenGrey, and ProQuest. Observational studies were included. The risk of bias was assessed using the Joanna Briggs Institute (JBI) checklist for studies reporting prevalence data. RStudio was used for meta-analyses. Cumulative evidence was evaluated according to Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria.
Results: From the 2607 identified records, 41 studies were included in the qualitative synthesis, and 28 were included in meta-analyses. A meta-analysis of 13 studies, including 1673 individuals, resulted in an overall lifetime prevalence of injuries due to FS per person of 25% (95% confidence interval [CI] = 19%-32%, I 2  = 88%). Considering a limited period (video-electroencephalographic [VEEG] monitoring days), a meta-analysis of 13 studies, including 848 individuals, resulted in an injury prevalence due to FS per person of .7% (95% CI = 0%-3%, I 2  = 73%). Also, a meta-analysis of eight studies, including 1000 individuals, resulted in a prevalence of injuries per FS of .1% (95% CI = 0%-.98%, I 2  = 49%). The certainty in cumulative evidence assessed by GRADE was rated "very low" for lifetime prevalence of injuries per person, "low" for prevalence per person during VEEG monitoring, and "moderate" for prevalence per number of FS.
Significance: Overall pooled lifetime prevalence of injuries due to FS per person was 25%. In comparison, the prevalence of injuries per person during VEEG monitoring and per functional seizure was .7% and .1%, respectively. [Correction added on 07 October 2023, after first online publication: In the preceding sentence, 'consecutively' was corrected to 'respectively'.] The evidence of the occurrence of injuries due to FS breaks the paradigm that epileptic seizures can cause injuries but FS cannot.
(© 2023 International League Against Epilepsy.)
Databáze: MEDLINE
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