Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content.

Autor: Bahr TM; Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA. tim.bahr@hsc.utah.edu.; Department of Neonatology, Intermountain Healthcare, Murray, UT, USA. tim.bahr@hsc.utah.edu., Tan S; Social, Statistical and Environmental Sciences Unit, RTI International, Washington, DC, USA., Smith E; Social, Statistical and Environmental Sciences Unit, RTI International, Washington, DC, USA., Beauman SS; Department of Pediatrics, University of New Mexico, Albuquerque, NM, USA., Schibler KR; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Grisby CA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Lowe JR; Department of Pediatrics, University of New Mexico, Albuquerque, NM, USA., Bell EF; Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Laptook AR; Department of Pediatrics, Brown University, Providence, RI, USA., Shankaran S; Department of Pediatrics, Wayne State University, Detroit, MI, USA., Carlton DP; Department of Pediatrics, Emory University, Atlanta, GA, USA., Rau C; Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA., Baserga MC; Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA., Flibotte J; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA., Zaterka-Baxter K; Social, Statistical and Environmental Sciences Unit, RTI International, Washington, DC, USA., Walsh MC; Division of Extramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA., Das A; Social, Statistical and Environmental Sciences Unit, RTI International, Washington, DC, USA., Christensen RD; Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA.; Department of Neonatology, Intermountain Healthcare, Murray, UT, USA., Ohls RK; Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2023 Nov; Vol. 43 (11), pp. 1368-1373. Date of Electronic Publication: 2023 Aug 18.
DOI: 10.1038/s41372-023-01751-z
Abstrakt: Objectives: To compare serum ferritin and RET-He values among extremely low gestational age neonates ELGANs with other markers of iron-deficient erythropoiesis.
Study Design: This is a secondary analysis of the NICHD Darbepoetin Trial. Study data from placebo recipients who had a serum ferritin, a RET-He, and a mean corpuscular volume (MCV) measurement within a 24-hour period were analyzed for correlation.
Results: Mixed linear regression models showed no association between ferritin and RET-He at both early (β = 0.0016, p = 0.40) and late (β = -0.0001, p = 0.96) time points. Positive associations were observed between RET-He and MCV at baseline, early, and late time points (p < 0.01, =0.01, <0.001, respectively), while ferritin was not associated with MCV at any time point.
Conclusions: Our study shows that RET-He is better correlated with MCV as a marker of iron-limited erythropoiesis than ferritin. The results suggest that ferritin is limited as a marker of iron sufficiency in premature infants.
Study Identification: FDA IND Number 100138; ClinicalTrials.gov number NCT03169881; NRN ID number NICHD-NRN-0058 (Darbe).
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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