Novel approaches to measure transfusion effectiveness.
| Autor: | Yee MEM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta.; Division of Hematology/Oncology, Department of Pediatrics, Emory University School of Medicine., Fasano RM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta.; Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia. |
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| Jazyk: | angličtina |
| Zdroj: | Current opinion in hematology [Curr Opin Hematol] 2023 Nov 01; Vol. 30 (6), pp. 230-236. Date of Electronic Publication: 2023 Aug 18. |
| DOI: | 10.1097/MOH.0000000000000783 |
| Abstrakt: | Purpose of Review: This review encompasses different considerations of transfusion effectiveness based upon clinical scenario and transfusion indication. Tissue oxygenation, cerebral metabolic oxygen use, and red blood cell (RBC) survival are important elements of transfusion effectiveness in individuals with acute and chronic transfusion requirements. Recent Findings: Noninvasive measures of tissue and cerebral oxygen extraction include near-infrared spectroscopy (NIRS) and specialized MRI sequences. RBC survival timepoints including 24 h posttransfusion recovery, 50% recovery timepoint, and mean potential lifespan may be accurately measured with biotin-labeling of RBC prior to transfusion. Labeling at different cell surface densities allows survival of multiple RBC populations to be determined. Summary: Although past trials of optimal transfusion thresholds have focused on Hb as a singular marker for transfusion needs, measures of oxygenation (via NIRS or specialized MRI) and RBC survival (via biotin labeling) provide the opportunity to personalize transfusion decisions to individual patient's acute health needs or chronic transfusion goals. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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