Atrial fibrillation ablation in patients with arrhythmia-induced cardiomyopathy: a prospective multicentre study.

Autor:	González-Ferrero T; Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain., Bergonti M; Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium.; Cardiovascular Research, GENCOR, University of Antwerp, Antwerp, Belgium.; Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland., López-Canoa JN; CIBERCV, Carlos III Health Institute, Madrid, Spain.; Department of Cardiology, University Hospital Complex of Pontevedra, Pontevedra, Spain., Arias FG; Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain., Eiras Penas S; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain., Spera F; Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium.; Cardiovascular Research, GENCOR, University of Antwerp, Antwerp, Belgium., González-Maestro A; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain., Minguito-Carazo C; Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain., Martínez-Sande JL; Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain., González-Melchor L; Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain., García-Seara FJ; Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain., Fernández-López JA; Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain., Álvarez-Castro E; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain., González-Juanatey JR; Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain., Heidbuchel H; Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium.; Cardiovascular Research, GENCOR, University of Antwerp, Antwerp, Belgium., Sarkozy A; Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium.; Cardiovascular Research, GENCOR, University of Antwerp, Antwerp, Belgium., Rodríguez-Mañero M; Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.; Translational Cardiology Group, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, 15706, A Coruña, Spain.; CIBERCV, Carlos III Health Institute, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	ESC heart failure [ESC Heart Fail] 2023 Oct; Vol. 10 (5), pp. 3055-3066. Date of Electronic Publication: 2023 Aug 18.
DOI:	10.1002/ehf2.14448
Abstrakt:	Aims: This study aims to investigate the clinical and biochemical characteristics of patients with atrial fibrillation (AF) referred for ablation who develop arrhythmia-induced cardiomyopathy (AiCM) as well as their long-term outcomes after catheter ablation (CA). Methods and Results: A prospective multicentre study was conducted on consecutive AF patients who underwent CA. AiCM was defined as the development of heart failure in the presence of AF and an improvement of left ventricular fraction by at least 10% at 6 months after ablation. A subgroup of patients underwent peripheral and left atrial blood samples [galectin-3, fatty acid-binding protein 4 (FABP4), and soluble receptor for advanced glycation end products (sRAGE)] at the time of the procedure. Of the 769 patients who underwent AF ablation, 135 (17.56%) met the criteria for AiCM. Independent predictors of AiCM included persistent AF, male gender, left atrial volume, QRS width, active smoking, and chronic kidney disease (CKD). Biomarker analysis revealed that sRAGE, FABP4, and galectin-3 levels were not predictive of AiCM development nor did they differ between groups or predict recurrence. There were no differences in AF recurrence between patients with and without AiCM (30.83% vs. 27.77%; P = 0.392) during a median follow-up of 23.83 months (inter-quartile range 9-36). Conclusions: In the subset of patients referred for AF ablation, the development of AiCM was associated with persistent AF and CKD. Biomarker analysis was not different between groups nor predicted recurrence. Patients with AiCM benefited from ablation, with a significant improvement in left ventricular ejection fraction and similar AF recurrence rates to those without AiCM. (© 2023 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text