Evaluation of a community-based aetiological approach for sexually transmitted infections management for youth in Zimbabwe: intervention findings from the STICH cluster randomised trial.

Autor:	Chikwari CD; MRC International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.; Biomedical Research and Training Institute, Harare, Zimbabwe., Simms V; MRC International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.; Biomedical Research and Training Institute, Harare, Zimbabwe., Kranzer K; Biomedical Research and Training Institute, Harare, Zimbabwe.; Clinical Research Department, London School of Hygiene & Tropical Medicine, London, UK.; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany., Dauya E; Biomedical Research and Training Institute, Harare, Zimbabwe., Bandason T; Biomedical Research and Training Institute, Harare, Zimbabwe., Tembo M; MRC International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.; Biomedical Research and Training Institute, Harare, Zimbabwe.; Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK., Mavodza C; Biomedical Research and Training Institute, Harare, Zimbabwe.; Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK., Machiha A; AIDS and TB Unit, Ministry of Health and Child Care, Harare, Zimbabwe., Mugurungi O; AIDS and TB Unit, Ministry of Health and Child Care, Harare, Zimbabwe., Musiyandaka P; Biomedical Research and Training Institute, Harare, Zimbabwe., Mwaturura T; Biomedical Research and Training Institute, Harare, Zimbabwe., Tshuma N; AIDS Healthcare Foundation, Zimbabwe., Bernays S; School of Public Health, University of Sydney, Sydney, Australia.; Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK., Mackworth-Young C; Biomedical Research and Training Institute, Harare, Zimbabwe.; Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK., Busza J; Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK., Francis SC; MRC International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Hayes RJ; MRC International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Ferrand RA; Biomedical Research and Training Institute, Harare, Zimbabwe.; Clinical Research Department, London School of Hygiene & Tropical Medicine, London, UK.
Jazyk:	angličtina
Zdroj:	EClinicalMedicine [EClinicalMedicine] 2023 Aug 03; Vol. 62, pp. 102125. Date of Electronic Publication: 2023 Aug 03 (Print Publication: 2023).
DOI:	10.1016/j.eclinm.2023.102125
Abstrakt:	Background: Young people are at high risk of sexually transmitted infections (STIs). We report STI testing uptake, prevalence and incidence within a community-based integrated HIV and sexual and reproductive health service for youth, being evaluated in a cluster randomised trial in Zimbabwe. Methods: This paper reports the intervention findings of the cluster randomised trial whereby STI testing was offered to all service attendees (16-24 years) in 12 intervention clusters over 12 months between October 5, 2020, and December 17, 2021, in Zimbabwe. Testing for Chlamydia trachomatis [CT] and Neisseria gonorrhoeae [NG] was offered to males and females with results available in one week and follow-up of test-positive clients by telephone. Trichomonas vaginalis [TV] testing was offered to females only with same day results and treatment. Youth testing positive for any STI were offered partner notification slips and free treatment for partners. This trial was registered with ISRCTN Registry, ISRCTN15013425. Findings: Overall, 8549/9891 (86.1%) eligible youth accepted CT/NG testing. Prevalence of CT and NG was 14.7% (95% CI 13.6-15.8) and 2.8% (95% CI 2.2-3.6) respectively. Combined prevalence of CT, NG or TV in women was 23.2% (95% CI 21.5-25.0). After adjusting for cluster, age and sex, the odds of NG were increased in those living with HIV (aOR 3.14, 95% CI 2.21-4.47). The incidence rate among those who initially tested negative for CT or NG was 25.6/100PY (95% CI 20.6-31.8). CT/NG treatment uptake was 924/1526 (60.6%). TV treatment uptake was 483/489 (98.8%). A partner returned for treatment for 103/1807 clients (5.7%). Interpretation: Our findings show high acceptability of STI testing among youth. STI prevalence was high particularly among females and youth with HIV, underscoring the need for integration of HIV and STI services. Funding: MRC/ESRC/DFID/NIHR (MR/T040327/1) and Wellcome Trust (206316/Z/17/Z). Competing Interests: Authors declare no competing interests. (© 2023 The Author(s).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu