Can vitamins improve periodontal wound healing/regeneration?

Autor: Fawzy El-Sayed KM; Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine, Cairo University, Giza, Egypt.; Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany., Cosgarea R; Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.; Department of Periodontology and Peri-implant Diseases, Philips University Marburg, Marburg, Germany.; Clinic for Prosthetic Dentistry, University Iuliu-Hatieganu, Cluj-Napoca, Romania., Sculean A; Department of Periodontology, University of Bern, Bern, Switzerland., Doerfer C; Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany.
Jazyk: angličtina
Zdroj: Periodontology 2000 [Periodontol 2000] 2024 Feb; Vol. 94 (1), pp. 539-602. Date of Electronic Publication: 2023 Aug 17.
DOI: 10.1111/prd.12513
Abstrakt: Periodontitis is a complex inflammatory disorder of the tooth supporting structures, associated with microbial dysbiosis, and linked to a number if systemic conditions. Untreated it can result in an irreversible damage to the periodontal structures and eventually teeth loss. Regeneration of the lost periodontium requires an orchestration of a number of biological events on cellular and molecular level. In this context, a set of vitamins have been advocated, relying their beneficial physiological effects, to endorse the biological regenerative events of the periodontium on cellular and molecular levels. The aim of the present article is to elaborate on the question whether or not vitamins improve wound healing/regeneration, summarizing the current evidence from in vitro, animal and clinical studies, thereby shedding light on the knowledge gap in this field and highlighting future research needs. Although the present review demonstrates the current heterogeneity in the available evidence and knowledge gaps, findings suggest that vitamins, especially A, B, E, and CoQ 10 , as well as vitamin combinations, could exert positive attributes on the periodontal outcomes in adjunct to surgical or nonsurgical periodontal therapy.
(© 2023 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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