Investigating the Potential Mechanisms and Therapeutic Targets of Inflammatory Cytokines in Post-stroke Depression.

Autor: Zhang Y; Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, 215000, China., Yang Y; Department of Neurology, Suzhou Yongding Hospital, Suzhou, 215028, China., Li H; Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, 215000, China., Feng Q; Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, 215000, China., Ge W; Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221600, China. gw1003@163.com., Xu X; Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, 215000, China. xingshunxu@suda.edu.cn.; Institute of Neuroscience, Soochow University, Suzhou, 215123, China. xingshunxu@suda.edu.cn.; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, 215123, Jiangsu, China. xingshunxu@suda.edu.cn.
Jazyk: angličtina
Zdroj: Molecular neurobiology [Mol Neurobiol] 2024 Jan; Vol. 61 (1), pp. 132-147. Date of Electronic Publication: 2023 Aug 17.
DOI: 10.1007/s12035-023-03563-w
Abstrakt: Post-stroke depression (PSD) affects approximately one-third of stroke survivors, severely impacting general recovery and quality of life. Despite extensive studies, the exact mechanisms underlying PSD remain elusive. However, emerging evidence implicates proinflammatory cytokines, including interleukin-1β, interleukin-6, tumor necrosis factor-alpha, and interleukin-18, play critical roles in PSD development. These cytokines contribute to PSD through various mechanisms, including hypothalamic-pituitary-adrenal (HPA) axis dysfunction, neurotransmitter alterations, neurotrophic factor changes, gut microbiota imbalances, and genetic predispositions. This review is aimed at exploring the role of cytokines in stroke and PSD while identifying their potential as specific therapeutic targets for managing PSD. A more profound understanding of the mechanisms regulating inflammatory cytokine expression and anti-inflammatory cytokines like interleukin-10 in PSD may facilitate the development of innovative interventions to improve outcomes for stroke survivors experiencing depression.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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