Experimental solubility of aripiprazole in supercritical carbon dioxide and modeling.

Autor: Ansari E; Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran., Honarvar B; Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran. honarvar2@gmail.com., Sajadian SA; Department of Chemical Engineering, Faculty of Engineering, University of Kashan, Kashan, 87317-53153, Iran.; South Zagros Oil and Gas Production, National Iranian Oil Company, Shiraz, 7135717991, Iran., Aboosadi ZA; Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran., Azizi M; Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Aug 17; Vol. 13 (1), pp. 13402. Date of Electronic Publication: 2023 Aug 17.
DOI: 10.1038/s41598-023-40537-3
Abstrakt: The solubility of compounds in supercritical carbon dioxide (SC-[Formula: see text]) has found crucial significance in the fabrication of micro/nano-scaled drugs. In this research, the solubility of Aripiprazole was measured in SC-[Formula: see text] at various temperatures (308-338 K) and pressures (12-30 MPa). Moreover, the experimental solubility results were correlated with several semi-empirical models (Chrastil, Bartle et al., Kumar & Johnston, Menden-Santiago & Teja, Sodeifian et al., and Jouyban et al.) as well as the modified Wilson model. The molar fraction of the drug in SC-[Formula: see text] varied in the range of [Formula: see text] to [Formula: see text]. The solubility highly depended on the operating pressure and temperature. The Chrastil (0.994), Jouyban et al. (0.993) and Sodeifian et al. (0.992) models showed the highest consistency with the obtained values. Furthermore, self-consistency tests were performed on the solubility of Aripiprazole in SC-[Formula: see text]. The approximate total enthalpy ([Formula: see text]), vaporization enthalpy ([Formula: see text]), and solubility enthalpy ([Formula: see text]) were also calculated.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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