Circulating IRF8-expressing CD123 + CD127 + lymphoid progenitors: key players in human hematopoiesis.

Autor: Liang KL; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent, Ghent, Belgium., Laurenti E; Department of Haematology, University of Cambridge, Cambridge, UK; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Taghon T; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent, Ghent, Belgium. Electronic address: Tom.Taghon@UGent.be.
Jazyk: angličtina
Zdroj: Trends in immunology [Trends Immunol] 2023 Sep; Vol. 44 (9), pp. 678-692. Date of Electronic Publication: 2023 Aug 15.
DOI: 10.1016/j.it.2023.07.004
Abstrakt: Lymphopoiesis is the process in which B and T cells, and innate lymphoid cells (ILCs) develop from hematopoietic progenitors that exhibit early lymphoid priming. The branching points where lymphoid-primed human progenitors are further specified to B/T/ILC differentiation trajectories remain unclear. Here, we discuss the emerging role of interferon regulatory factor (IRF)8 as a key factor to bridge human lymphoid and dendritic cell (DC) differentiation, and the current evidence for the existence of circulating and tissue-resident CD123 + CD127 + lymphoid progenitors. We propose a model whereby DC/B/T/ILC lineage programs in circulating CD123 + CD127 + lymphoid progenitors are expressed in balance. Upon tissue seeding, the tissue microenvironment tilts this molecular balance towards a specific lineage, thereby determining in vivo lineage fates. Finally, we discuss the translational implication of these lymphoid precursors.
Competing Interests: Declaration of interests No interests are declared.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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