A Retrospective Analysis of 83 Patients with Testicular Mass Who Underwent Testis-Sparing Surgery: The Eurasian Uro-oncology Association Multicenter Study.

Autor:	Keske M; University of Health Sciences Medical Faculty of Kayseri, Kayseri City Hospital, Kayseri, Turkey., Canda AE; Department of Urology, School of Medicine, Koç University, Istanbul, Turkey., Karadag MA; University of Health Sciences Medical Faculty of Kayseri, Kayseri City Hospital, Kayseri, Turkey., Çiftçi H; Department of Urology, School of Medicine, Harran University, Sanliurfa, Turkey., Erturhan S; Department of Urology, School of Medicine, Gaziantep University, Gaziantep, Turkey., Kactan C; Department of Urology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Soytas M; Department of Urology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Özkaya F; Department of Urology, School of Medicine, Atatürk University, Erzurum, Turkey., Ozbey I; Department of Urology, School of Medicine, Atatürk University, Erzurum, Turkey., Ordek E; Department of Urology, School of Medicine, Harran University, Sanliurfa, Turkey., Atmaca AF; Department of Urology, Memorial Ankara Hospital, Ankara, Turkey., Yildirim A; Department of Urology, School of Medicine, Medeniyet University, Istanbul, Turkey., Sahin S; Department of Urology, University of Health Sciences Affiliated with Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey., Colakoglu Y; Department of Urology, University of Health Sciences Affiliated with Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey., Boylu U; Department of Urology, İstinye University Faculty of Medicine, Istanbul, Turkey., Erol B; Department of Urology, School of Medicine, Medeniyet University, Istanbul, Turkey., Caskurlu T; Department of Urology, School of Medicine, Medeniyet University, Istanbul, Turkey., Kiremit MC; Department of Urology, School of Medicine, Koç University, Istanbul, Turkey., Cakici OU; Department of Urology, Medical Park Ankara Hospital, Ankara, Turkey., Sonmez G; Department of Urology, Erciyes University Faculty of Medicine, Kayseri, Turkey., Kılıçarslan H; Department of Urology, Uludag University, School of Medicine, Bursa, Turkey., Akbulut Z; Department of Urology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Kaygısız O; Department of Urology, Uludag University, School of Medicine, Bursa, Turkey., Bedir S; Department of Urology, University of Health Sciences Affiliated with Gulhane Training and Research Hospital, Ankara, Turkey., Vuruskan H; Department of Urology, Uludag University, School of Medicine, Bursa, Turkey., Bozkurt YE; Department of Urology, Celal Bayar University, School of Medicine, Manisa, Turkey., Aydin HR; Department of Urology, University of Health Sciences Affiliated with Kanuni Training and Research Hospital, Trabzon, Turkey., Oguz U; Department of Urology, Giresun University, School of Medicine, Giresun, Turkey., Basok EK; Department of Urology, Medical Park Izmir Hospital, Izmir, Turkey., Gumus BH; Department of Urology, Celal Bayar University, School of Medicine, Manisa, Turkey., Tuncel A; Department of Urology, Ankara City Hospital, Ankara, Turkey., Aslan Y; Department of Urology, Ankara City Hospital, Ankara, Turkey., Hamidi N; Department of Urology, Ankara Abdurrahman Yurtaslan Oncology Hospital, Ankara, Turkey., Müslümanoğlu AY; Department of Urology, Bagcilar Training and Research Hospital, Istanbul, Turkey., Dinçer M; Department of Urology, Bagcilar Training and Research Hospital, Istanbul, Turkey., Balbay D; Department of Urology, School of Medicine, Koç University, Istanbul, Turkey., Albayrak S; Department of Urology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Laguna MP; Department of Urology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Urologia internationalis [Urol Int] 2023; Vol. 107 (9), pp. 857-865. Date of Electronic Publication: 2023 Aug 17.
DOI:	10.1159/000531645
Abstrakt:	Introduction: Herein, we analyzed the histopathological, oncological and functional outcomes of testis-sparing surgery (TSS) in patients with distinct risk for testicular cancer. Methods: This is a multicenter retrospective study on consecutive patients who underwent TSS. Patients were categorized in high- or low-risk testicular germ cell tumor (TGCT) according to the presence/absence of features compatible with testicular dysgenesis syndrome. Histology was categorized per size and risk groups. Results: TSS was performed in 83 patients (86 tumors) of them, 27 in the high-risk group. Fifty-nine patients had a non-tumoral contralateral testis present. Sixty masses and 26 masses were benign and TGCTs, respectively. No statistical differences were observed in mean age (30.9 ± 10.32 years), pathological tumor size (14.67 ± 6.7 mm) between risk groups or between benign and malignant tumors (p = 0.608). When categorized per risk groups, 22 (73.3%) and 4 (7.1%) of the TSS specimens were malignant in the high- and low-risk patient groups, respectively. Univariate analysis showed that the only independent variable significantly related to malignant outcome was previous history of TGCT. During a mean follow-up of 25.5 ± 22.7 months, no patient developed systemic disease. Local recurrence was detected in 5 patients and received radical orchiectomy. Postoperative testosterone levels remained normal in 88% of those patients with normal preoperative level. No erectile dysfunction was reported in patients with benign lesions. Conclusion: TSS is a safe and feasible approach with adequate cancer control, and preservation of sexual function is possible in 2/3 of patients harboring malignancy. Incidence of TGCT varies extremely between patients at high and low risk for TGCT requiring a careful consideration and counseling. (© 2023 S. Karger AG, Basel.)
Databáze:	MEDLINE
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