Sharp-wave-ripple-associated activity in the medial prefrontal cortex supports spatial rule switching.

Autor:	den Bakker H; Neuro-Electronics Research Flanders, Leuven, Belgium; Brain & Cognition, KU Leuven, Leuven, Belgium., Van Dijck M; Neuro-Electronics Research Flanders, Leuven, Belgium; Department of Chemistry, KU Leuven, Leuven, Belgium., Sun JJ; Neuro-Electronics Research Flanders, Leuven, Belgium., Kloosterman F; Neuro-Electronics Research Flanders, Leuven, Belgium; Brain & Cognition, KU Leuven, Leuven, Belgium. Electronic address: kloosterman.fabian@gmail.com.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112959. Date of Electronic Publication: 2023 Aug 16.
DOI:	10.1016/j.celrep.2023.112959
Abstrakt:	Previous studies have highlighted an important role for hippocampal sharp-wave ripples in spatial alternation learning, as well as in modulating activity in the medial prefrontal cortex (mPFC). However, the direct influence of hippocampal sharp-wave ripples on mPFC activity during spatial alternation learning has not been investigated. Here, we train Long Evans rats on a three-arm radial maze to perform a sequence of alternations. Three alternation sequences needed to be learned, and while learning a sequence, the activity in the mPFC was inhibited either directly following sharp-wave ripples in the hippocampus (on-time condition) or with a randomized delay (delayed condition). In the on-time condition, the behavioral performance is significantly worse compared to the same animals in the delayed inhibition condition, as measured by a lower correct alternation performance and more perseverative behavior. This indicates that the activity in the mPFC directly following hippocampal sharp-wave ripples is necessary for spatial rule switching. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu