Differentiating thyroid nodules parathyroid lesions using 2D-shear-wave elastography: a novel approach for enhanced diagnostic accuracy.

Autor: Stoian D; Discipline of Endocrinology, Second Department of Internal Medicine, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.; Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babeş' University of Medicine and Pharmacy, Timişoara, Romania., Borlea A; Discipline of Endocrinology, Second Department of Internal Medicine, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.; Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babeş' University of Medicine and Pharmacy, Timişoara, Romania., Taban L; Clinic of Endocrinology, Timiş County Emergency Clinical Hospital, Timisoara, Romania., Maralescu FM; Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babeş' University of Medicine and Pharmacy, Timişoara, Romania.; Discipline of Nephrology, Second Department of Internal Medicine, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania., Bob F; Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babeş' University of Medicine and Pharmacy, Timişoara, Romania.; Discipline of Nephrology, Second Department of Internal Medicine, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania., Schiller O; Dialysis Unit, Dialysis Medical Center B Braun Avitum, Timisoara, Romania., Schiller A; Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babeş' University of Medicine and Pharmacy, Timişoara, Romania.; Discipline of Nephrology, Second Department of Internal Medicine, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania., Neagoe O; Second Discipline of Surgical Semiology, First Department of Surgery, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
Jazyk: angličtina
Zdroj: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Jul 31; Vol. 14, pp. 1231784. Date of Electronic Publication: 2023 Jul 31 (Print Publication: 2023).
DOI: 10.3389/fendo.2023.1231784
Abstrakt: Differentiating between thyroid and parathyroid lesions by means of ultrasound can be a challenge in some cases. This study explores the diagnostic efficacy of bidimensional shear wave elastography planewave ultrasound (2D SWE PLUS) as an auxiliary technique in distinguishing these superficial structures. We evaluated 86 cases, presenting with concurrent thyroid nodules and hyperparathyroidism, through conventional ultrasound and 2D SWE PLUS, employing an Aixplorer Supersonic Mach30 with a 5-18 MHz linear probe. Statistically significant differences were observed for the elasticity index (EI) between parathyroid and normal thyroid tissue (p<0.0001, U=291), and between parathyroid lesions and thyroid nodules (p<0.0001, U=248.5). An area under the curve (AUC) of 0.961, with an optimal cut-off value of ≤8.9 kPa, was established to effectively distinguish parathyroid tissue from normal thyroid tissue (sensitivity of 91.9%; specificity of 97.5%). Furthermore, an AUC of 0.963 and an optimal cut-off of 9.24 kPa (sensitivity of 94.2%, specificity of 91.1%) were determined for parathyroid vs thyroid lesions. Elasticity values were significantly elevated in the cancer group compared to benign thyroid nodules (p<0.0001). Our findings suggest that 2D SWE PLUS is an effective tool in differentiating between thyroid nodules and parathyroid lesions, enhancing diagnostic performance in neck ultrasonography.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Stoian, Borlea, Taban, Maralescu, Bob, Schiller, Schiller and Neagoe.)
Databáze: MEDLINE